Tujuan penelitian untuk mengetahui pengaruh dari variabel ukuran perusahaan, opini audit, umur perusahaan, profitabilitas, dan solvabilitas. Data populasi mencakup perusahaan jasa yang terdaftar dalam Bursa Efek Indonesia (BEI) pada tahun 2016-2018. Sampel data yang digunakan merupakan hasil dari teknik purposive sampling dan jumlah sampel yang layak digunakan sebanyak 192 perusahaan. Selama penelitian dilaksanakan, metode yang digunakan yaitu metode analisis regresi logistik dengan penggunaan program SPSS 24. Berdasarkan hasil pengujian oleh peneliti, variabel yang diketahui dapat mempengaruhi audit delay yakni ukuran perusahaan dan umur perusahaan yang bersifat negatif dan secara signifikan. Namun, variabel yang tidak berpengaruh terhadap audit delay yakni opini audit, profitabilitas, dan solvabilitas.
Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis. Mycobacterium tuberculosis will form the primary focus or Ghon focus in the lungs of infected people. The primary focus can break and get into the bloodstream and/or lymph to the entire body, including the central nervous system, especially the brain. Tuberculosis infection in the brain can cause microglia secrete inflammatory factors such as TNF-α and IL-1β is emerging as the body's immune response. The factors that can trigger microglia to secrete iNOS (Inducible Nitric Oxide Synthase) in order to protect the brain from attacking bacteria. iNOS is shown to have an important role in tuberculosis infection in the brain. TNF-α is a pro-inflammatory cytokine which is mostly produced by macrophages/microglia through several mechanisms. Therefore, to investigate how the expression of TNF-α and iNOS in the brain tissue of the mice is not infected with tuberculosis, tuberculosis infection with an incubation period of 8 weeks and 16 weeks. This study is a semiquantitative study by comparing the amount of expression of TNF-α and iNOS and all three groups of samples with treatment as has been mentioned. The expressions observation of TNF-α and iNOS in brain cell tissue of mice was conducted using immunohistochemical staining, and was seen in a microscope with a magnification of ×100. Brain cells that express TNF-α and iNOS are brown core, cytoplasm and cell walls. The results were obtained by the longer exposure to infection of the higher expression of TNF-α (r > 0688) and the expression of iNOS decreased (−0.993).
Bali Island is a famous tourist destination in the world and this has made it a gathering hub and multicultural meeting center for tourists from several countries, thereby, raising concern on the possibility of the area losing its traditional Balinese architecture. It is necessary to make adjustments by adopting the shape of the old Balinese building. This means the emergence of new functions is not a taboo but a new design challenge, therefore, the traditional Balinese architecture and theater provisions were combined to produce a neo-vernacular architecture by using descriptive qualitative method. This led to the application of Asta Kosala-kosali in the theater space, modification on the roof, body and legs shape of the Balinese building, and the integration of the construction system and materials in the Balinese theater architecture. © 2020 Alan Darma Saputra, Rahadhian Prajudi Herwindo, Yohanes Karyadi Kusliansjah
<p><em><span lang="EN-US">Bali is a gathering of tourist who come from all over the country. Because of this, a mixture of cultures emerged on the island ranging from lifestyles such as clothing, language, food to architecture, so that over time Balinese architecture became faded. To prevent this, it is necessary to preserve traditional Balinese architecture by applying traditional forms of architecture to new buildings, especially the theater (as buildings that become icons of Balinese culture). The theory chosen was traditional Balinese architecture, contemporary theater provisions and neo-vernacular architecture. The method used to trace the case is descriptive qualitative by taking important aspects in neo-vernacular architecture as a meeting point between traditional Balinese architecture and neo-vernacular, then these aspects are used as a benchmark in the design transformation from what was originally a small span building to a wide span with a theater function. The study results obtained are guidelines and examples of the application of Asta Kosala-kosali in contemporary theater on spatial, roof, body and foot structures of Balinese architecture and the combination of Balinese architectural tectonics in contemporary art theater. This journal has a high urgency because at present there are many functions that require wide-span buildings, so that Balinese architecture can be applied to buildings without eliminating the culture or noble values in it.</span></em></p>
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