Cystic lesions of neck containing thymic tissue are rare and usually difficult to diagnose. Postulated hypothesis for this entity is the persistence and/or degeneration of thymopharyngeal duct derived from pharyngeal pouch endoderm. We report a unique case of persistent thymopharyngeal duct which was diagnosed antenatally at 30 weeks’ gestation, and it preserved its connection with the pharynx. Postnatal radiological studies were non-specific and misleading, and diagnosis was confirmed by histological examination of the excised specimen.
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