Isomerization to linear ketones is a valuable transformation of 1,2-disubstituted cyclopropanols proceeding through radical intermediates. Despite simplicity of this reaction, the known protocol required stoichiometric amounts of both an oxidant and a reducing agent. In this article, we report a cata- [a]
The total synthesis of epothilone D with six-fold application in the intermediate stages of successive cyclopropanation -opening or cleavage of the three-membered ring was performed. These transformations underlie the new stereoselective method developed for coupling fragments С 7 -С 12 and С 13 -С 21 in the target molecule.
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