SummaryNew‐onset refractory status epilepticus (NORSE) is a rare condition where refractory seizures occur with no obvious cause in an otherwise healthy individual. We report here the first case of a patient with NORSE caused by Jamestown Canyon virus, an emerging virus throughout North America. This is the first patient with Jamestown Canyon virus encephalitis treated by a specific antiviral agent, in this case intravenous ribavirin, with electroencephalography (EEG) evidence of improvement. This is finally the first reported death caused by this virus, here secondary to intensive care unit complications. Therefore, Jamestown Canyon virus should be considered as a NORSE etiology, and ribavirin may be an effective treatment of that condition, especially if used early.
ln order to cvalu;ne the association between Camfrylobacier pylon· and gastritis. two hiopsics were taken from the duodenal bulb, antrum, hody and fund us (and from lesions if there were any) in 100 consecutive patients referred to this gastro~copic clin ic For each ~ite, one hiopsy was for histology and C pylon de tection by Warthin-Starry stai n ing, ;,nd the second biopsy wns fo r culcu re. In addition, for each patient a gas tric h rushing was Gram stained. Twen ty-one patients were excluded from the study. Among the rl'maining, 13 patient~ h ad po:,i tivc biopsy cu lture fo r C f1ylon and, uf these , 30 (9 1 "i, ) had gastri tis (including 23 wi th active chronic gastritis). Thi.! culture sensi ti vi ty increased with the n umber of b iopsies. Forty-two pa tients had n positive brush ing specimen, of which 30 ( 71 '\,) had gastri tis. Gram stain on a brushing specimen h ad a sensitivity of84 .8";, in comparison w ith the biopsy cu lture. Of the 2 3 patien ts w ith positive Warth in-Starry stai n , 19 (81'\,) had an histology of gastrnis. T here was a strong correlation between the presence of C fry/on in the stomach mucosa and the gastritis. T he incidence of C frylori associated gastri tis is similar in Quebec to other pares of the world . The b iopsy cultu re is a simple and specific test, and at k ast two biopsies arc necessar y for a good sensit ivity. Gram stain on a b rushing specimen is an aJequate test for rapid detection nfC f)ylori in the stomach. Can J human s tomach have occurrcJ ~poradically over the l,1s1 cen t ury ( 1.21 However, it was only in 1982 that a microacroph ilic campylobacter-like organism was isolated by Marshall and Warren ( 'll from gastric antra l b iopsy specimens This mitial publica tion sparked off worlJ wide enth usiasuc research into this bac terium now named Camfrylobacrer fry/on (4.5). Since th.is time, a numherofscuJ · ies have shown an association between the p resence of C /;ylori in gastric mucosa a nd h istologicall y confi r med gastri tis However, there is sri ll some d iscussion whether the organ ism has a ca usative role or is simply a secondary invader.With chis sw dy, it wa~confi rmed that C pylori was correlated with gastritis anJ then differen t methods for C pylori decec· tion in the huma n srnmc1ch were eval uated T he literatu re was also review<. Microbiology: Samples for culture were immediately immersed in 5 ml of thioglycolate b roth , transported to the laboratory within 2 h of collection and macerated in 2 ml of the same broth . One drop was the n p lated on b lood agar (trypticase soy agar with sheep blood 5'\,) and choce,,are agar (GC agar, bio-X 1% and hemoglobin 1%) a nd incubated microaerophilically in anaerobic jars fo r seven days at 37°C. T hegaspak (CampyPa k, BB L) was replaced every 24 h. C pylori, when isolated. was identified using d irect examination with Gram sta in , oxyJase, cata lase, oxydario nfcrmenrarion test with pu rple bromocresol. nitrate reduction , h ip p urace hydrolysis, urease (C h ristensen's u rea med ium), ...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.