No abstract

Cannabis products (marijuana, weed, hashish) are among the most widely abused psychoactive drugs in the world, due to their euphorigenic and anxiolytic properties. Recently, hair analysis is of great interest in analytical, clinical, and forensic sciences due to its non-invasiveness, negligible risk of infection and tampering, facile storage, and a wider window of detection. Hair analysis is now widely accepted as evidence in courts around the world. Hair analysis is very feasible to complement saliva, blood tests, and urinalysis. In this review, we have focused on state of the art in hair analysis of cannabis with particular attention to hair sample preparation for cannabis analysis involving pulverization, extraction and screening techniques followed by confirmatory tests (e.g., GC–MS and LC–MS/MS). We have reviewed the literature for the past 10 years’ period with special emphasis on cannabis quantification using mass spectrometry. The pros and cons of all the published methods have also been discussed along with the prospective future of cannabis analysis.

This paper describes the synthesis of a new series of trifluoromethylpyrimidine and their potential antimicrobial evaluation. We have prepared 10 novel pyrimidine derivatives in high yields and short reaction time using microwave irradiation. Compounds 4a,b and 6a,b showed good antimicrobial activity against Gram-positive bacteria; Clostridium perfringens, Bacillus pumilus and Enterococcus faecalis. These compounds were found to be the most potent antimicrobials compared to ampicillin, tetracycline, and streptomycin that showed no activity against Enterococcus faecalis. Compounds 4a,b and 6a,b exhibited great antimicrobial potency against all tested bacteria strains at a MIC of 3.125-100 μg/mL whereas only 4a showed the antimicrobial activity against Gram-negative bacteria Klebsiella pneumonia with a MIC value 12.5 μg/mL.

Correction for ‘In situ synthesis of chiral AuNCs with aggregation-induced emission using glutathione and ceria precursor nanosheets for glutathione biosensing’ by Mohamed Ibrahim Halawa et al., Analyst, 2022, https://doi.org/10.1039/d2an00939k.

In the present study, a mediator release test (MRT) strategy is designed for photoluminescent sensing of glutathione (GSH). On the basis of the redox reaction of GSH and cerium-based nanosheets...