Non-alcoholic fatty liver disease (NAFLD) is one of chronic liver and defines by
fat accumulation ≥5% in liver which can progresses to non-alcoholic steatohepatitis
(NASH). NAFLD related to obesity as well as non obese individuals. Adiponectin is a
cytokine secreted from adipose tissue involved NAFLD pathogenesis and liked with
obesity. Irisin is a myokine, has a convenient effect against metabolic diseases such as
obesity, disylipemia diabetes type 2 and reversed liver steatosis and may be related
with NAFLD. Vitamin D is one of the fat soluble vitamins and more precisely as a
pro-hormone through its metabolite (1,25(OH)2 cholecalciferol) the major steroid
hormone. After the skin exposure to the light, vitamin D undergoes to activation through
two successive hydroxylation reactions in liver and kidney. Several metabolic diseases
such as dyslipidaemia, obesity, hypertension, T2D and metabolic syndrome (MS) have been
related to vitamin D deficiency.
One of the most common public liver diseases over the world is fatty liver which contain alcoholic and non-alcoholic fatty liver. One-fourth among general population are impact Non-Alcoholic Fatty Liver Disease (NAFLD) in the worldwide.Retinol binding protein 4 (RBP4) is known as an adipokine, mainly synthesized and secreted from the liver and form adipose tissues. RBP4 acts as a transporter and specifically bound to retinol from liver to others tissues. Visfatin is an adipocytokine and mainly produced from visceral fat tissue, skeletal muscles as well as liver. Vitamin A absorbed, transported as retinyl esters to the liver then hydrolyzed to the retinol form and storage in hepatic stellate cells (HSCs) after reesterified with riglycerides. Hepatic retinyl esters are hydrolyzed to retinol and binds to its carrier RBP4 then transport to the target tissues. Methods: Ninety serum blood samples were collected and distributed into three groups: First group (G1) contained of (34) patients of obese NAFLD. Second group (G2) contained of (26) non obese NAFLD and control patients (G3) contained of (30) patients. Ultrasound was used to confirm the diagnosis of nonalcoholic fatty liver disease by examining the abdomen.
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