This review discusses the functions of soluble sugars (as compatible solutes) in supporting the growth of plants under osmotic stress, and the perspectives of research on the role of the associated microorganisms as a new approach in providing these solutes to plants. Previous findings have suggested that plants sacrifice from their energy and reserves to build up compatible solutes and to perform various functions; as osmo-protectants and possibly to stabilize biomolecules, and to achieve osmotic adjustment between the plants and their environments. However, many reports have shown contradictory and controversial results, since there was no consistency in the response of plants to various types of abiotic stresses, during various stages of growth and development. Recent outcomes have revealed that other soluble sugars such as trehalose, might accumulate under extreme environmental conditions by various groups of microorganisms (bacteria and fungi), to support the growth of native plants and crops. This review reports the possibility of the presence of trehalose in the native plants of Qatar, as well as the associated microorganisms. However, articles in large numbers from around the world have shown no clear indication that this sugar accumulates in these plants, and no attempts have been made to measure it. More studies are concentrating on the perspectives of research, regarding the possible role of these soluble sugars that are synthesized in bacteria and fungi, to support the growth of plants in the Arabian Gulf region with a new look of innovative researches, to introduce traits using modern gene technology to build trehalose in some crops. The possible negative impact of the accumulation of compatible solutes in general and the soluble sugars in particular on plant metabolism and growth is discussed, presenting some evidences that have been raised during the last four decades and examples from higher plants.