ObjectiveTo estimate the incidence rate of type 1 diabetes in the urban area of Santiago, Chile, from March 21, 1997 to March 20, 1998, and to assess the spatio-temporal clustering of cases during that period. Methods All sixty-one incident cases were located temporally (day of diagnosis) and spatially (place of residence) in the area of study. Knox's method was used to assess spatiotemporal clustering of incident cases. ResultsThe overall incidence rate of type 1 diabetes was 4.11 cases per 100,000 children aged less than 15 years per year (95% confidence interval: 3.06-5.14). The incidence rate seems to have increased since the last estimate of the incidence calculated for the years 1986-1992 in the metropolitan region of Santiago. Different combinations of space-time intervals have been evaluated to assess spatio-temporal clustering. The smallest p-value was found for the combination of critical distances of 750 meters and 60 days (uncorrected p-value = 0.048). Conclusions Although these are preliminary results regarding space-time clustering in Santiago, exploratory analysis of the data method would suggest a possible aggregation of incident cases in space-time coordinates. Resumo Objetivo97 97 97 97 Rev Saúde Pública 2001;35(1):96-100 www.fsp.usp.br/rsp Incidence rate and spatio-temporal of type 1
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