The discovery of antibiotics around the middle twentieth century led to a decrease in the interest in antimycobacterial fatty acids. In order to re‐establish the importance of naturally abundant fatty acid, a series of fatty acid‐thiadiazole derivatives were designed and synthesized based on molecular hybridization approach. In vitro antimycobacterial potential was established by a screening of synthesized compounds against Mycobacterium tuberculosis H37Rv strain. Among them, compounds 5a, 5d, 5h, and 5j were the most active, with compound 5j exhibiting minimum inhibitory concentration of 2.34 μg/ml against M.tb H37Rv. Additionally, the compounds were docked to determine the probable binding interactions and understand the mechanism of action of most active molecules on enoyl‐acyl carrier protein reductases (InhA), which is involved in the mycobacterium fatty acid biosynthetic pathway.
A forthright, effectual and more viable catalyst-free method has been developed for the synthesis of quinolone and pyrazole ring system in glycerol to achieve yields that were equivalent to or better than, those in conventional media. It is notable that the reaction was exclusively carried out in glycerol–acetic acid system, representing methodology is highly valuable from both environmental and economic points of view
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.