The body system is dependent on each other through communication, cancer development can be supported by the new cancerinduced pathological systemic networks (CISPN), and the entire organism is "cancerized." The significant anomaly in the transition of epithelial cells to mesenchymal cells plays a vital role in neural crest migration. The metastatic program follows a transformed cellular communication process that, activated once, causes dispersed tumors at a distance from the original site. This review aims to provide an idea of various systemic and new hallmarks and several altered networking processes that eventually end up causing cancer.
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