Background:
Due to arising threats of microbial infectious diseases in the human population, and the development of resistance against therapeutics, novel medicinal agents are required to counteract antimicrobial resistance. Heterocyclic rings such as indole or pyrrole, have been acknowledged to possess various biological properties like antimicrobial, anticancer, antiviral, antitubercular, etc and metals such as platinum, vanadium, zinc, selenium, etc. also show therapeutic actions. Thus, this work focuses to turn heterocyclic ring compound (isatin) and metal (zinc) into a drug having antimicrobial potential.
Objective:
The objective of the study was to synthesize zinc complexes of isatin Schiff bases and evaluate for antibacterial and antifungal activity.
Methods:
Herein, the conventional method was used for the synthesis of isatin Schiff bases from isatin and different monosubstituted amines. Then, zinc complexes were prepared by using isatin Schiff bases and zinc acetate. Physicochemical characteristics such as Rf value and melting point were determined by TLC and decibel melting point apparatus respectively. All the complexes were characterized by FT-IR and 1H NMR techniques. Further, the final zinc complexes were screened for antimicrobial potential by the serial dilution method. Some computational studies were also done with the help of MOPAC 2016.
Result:
In the present work, 14 complexes of zinc are obtained in harmonious yield from isatin Schiff bases using zinc acetate. Amongst the studied complexes, Z-3, Z-4, and Z-12 depicted maximum antimicrobial activity.
Conclusion:
14 complexes of zinc were prepared by using 14 isatin Schiff bases which were in turn prepared by isatin and different mono-substituted amines. Characterization of these complexes was done by using FT-IR and 1H NMR. All prepared metal complexes were obtained in appropriate yield. The synthesized complexes were screened for their antimicrobial potential.
A
BSTRACT
Introduction:
Regeneration, in the field of endodontics, is the process of restoring and maintaining both architectural form and biological functions of damaged tooth. Presently, regenerative endodontics is not hypothetical and is an alternative to conventional apexification procedures. There is a deficient knowledge concerning the role of intracanal medicaments and their effect on dental stem cells.
Aim:
The aim of this study was to evaluate the effectiveness of commonly used intracanal medicaments on the viability of dental stem cells of the apical papilla (SCAPs).
Materials and Methods:
SCAPs were cultured and subjected to various concentrations including triple antibiotic paste, double antibiotic paste, Augmentin, and calcium hydroxide (Ca(OH)
2
). Viable percentage of stem cell counts was obtained 3 days after treatment.
Results:
All three antibiotics used hereby significantly decreased SCAP cell survival at particular concentrations, whereas Ca(OH)
2
showed stimulating effect on SCAP survival.
Conclusion:
As per results obtained within limitations of this study, use of Ca(OH)
2
in regenerative endodontics in comparison to different commonly used antimicrobial combinations is recommended. Hereby, for clinical use, we suggest adequate concentrations of antimicrobials with adequate antibacterial efficacy should be used.
Synthesis,Antiinflammatory and Analgesic Activity Evaluation of Some 2-(9-Acridinylamino)pyridines and 2-(9-Acridinylamino/imino)thiazolines.-The title compounds, e.g. (III) and (V), have been evaluated for their biological activity. (IIId) shows good analgesic activity. -(SONDHI, S. M.; SINGHAL, N.; VERMA, R. P.; RAGHUBIR, R.; GOEL,A.K.; PATNAIK,G.K.; Indian J. Chem., Sect. B: Org.
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