The results of this study indicate that testicular torsion and its treatment with detorsion is an example of ischemia-reperfusion injury, producing measurable changes in malondialdehyde in humans. Thus, serum malondialdehyde could be used to determine the extent of injury.
Obesity and related diseases represent greatest threats to human health. Nanoparticles (NPs) serve to reduce toxicity; reinforce bioactivity and improve targeting. This study was intended to investigate the antiobesity and antioxidant activities of selenium and zinc oxide nanoparticles. Methods: Twenty four adult male rats were divided into four groups, group1 control rats fed normal diet and the other three groups were fed high fat diet (HFD) for 10 weeks to induce obesity and injected intraperitoneally with saline, SeNPs (30μg/kg b.wt) and ZnONPs (5mg/kg b.wt) respectively on the last two weeks of feeding (9th and 10th). Results: HFD increased body weight, oxidative stress as indicated by elevated lipid peroxidation and decreased glutathione and catalase levels, increased significantly serum lipid fractions, leptin, liver enzymes, creatinine and uric acid. While causing a substantial decrease in HDL-C and thyroid hormone T4 levels. The results confirmed that treatment with SeNPs and ZnONPs significantly reduced body weight, MDA and improved liver and kidney functions, ameliorated serum lipid fractions level and significantly increased glutathione, catalase, HDL-C and thyroid hormone. Conclusion: SeNPs and ZnONPs significantly mitigate hyperlipidemia and oxidative stress. So, they might be potential candidate for obesity amelioration.
HighlightsForeign bodies in the urinary bladder always act as a nidus for formation of a calculus.This was a rare case of bladder stones secondary to an iatrogenic injury to the bladder in the form of prolene stitches used to repair an inguinal hernia protruding into the bladder.The patient most likely had a full bladder at the time of hernia repair or the bladder was part of the contents of the hernia sac.This case illustrates the need to ensure that the bladder is empty prior to pelvic surgery and for surgeons to have a good understanding of inguinal anatomy to avoid injuring the contents of the hernia sac.
In a growing child a prolonged forgotten 'J' stent is very likely to undergo spontaneous fracture due to the stress exerted on it as a result of cranio-caudal growth of the child. In adults, prolonged forgotten stents become calcified, brittle and lose tensile strength after more than one year of placement and may fracture either spontaneously or during attempts to remove them endoscopically. In patients producing hypotonic urine such as patients with moderate renal failure, a prolonged forgotten stent may remain little affected by the passage of time.
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