Available pharmaceutical information is often characterized by inadequacy, and inaccuracy, which compromise its quality and usefulness. This study was carried out to examine staff characteristics, organizational and technical aspects that affect the quality of pharmaceutical information. A crosssectional, descriptive study targeting pharmacy staff in public primary care facilities was carried out in Nairobi County. Thirty one facilities were surveyed and a pre-tested semi-structured questionnaire was administered to 31 pharmacy staff. Adequacy and accuracy of records and reports was assessed using a checklist. District pharmaceutical facilitators were interviewed as key informants. Quantitative data was analyzed using Predictive Analytics Software version 22. Qualitative data was analyzed through thematic content analysis. Staff characteristics obtained were in-service training in 9(29%), good knowledge and skills in data entry in 25(81%) and low levels of motivation in 13(42%) staff. Pearson's chi square tests revealed significant relationships between cadre of staff and knowledge and skills. Organizational aspects were low numbers of pharmaceutical technologists numbering 11(36%), supportive supervision feedback in only 4(15%) facilities, and lack of written roles and responsibilities in 21(68%) facilities. Significant relationships were found between having written roles and responsibilities and ability to enter data accurately. Technical aspects were high availability of computers and data management software in 30(97%) facilities, but use of data management software in only 6(20%) facilities. A significant relationship was found between use of data management software and accuracy of stock records. The study concluded that in-service training had weaknesses, management support was inadequate and use of information technology was low. Recommendations were made to improve in-service training, strengthen management support; and promote use of data management software.
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