No abstract

Chlorite is abundant at hypocentral depths in subduction zones and is likely to play a key role in controlling megathrust slow slip and catastrophic rupture. However, no data exist on the frictional properties of chlorite(-rich) fault rocks under the hydrothermal conditions relevant for the subduction seismogenic zone. We report results from experiments conducted under such conditions, using chlorite powders prepared from single crystal clinochlore (Mg-chlorite), as well as limited experiments using a stack of single crystal sheets. Shear experiments were carried out at effective normal stresses (σ n ) of 100 to 400 MPa, pore fluid pressures (P f ) of 50 to 220 MPa, and at temperatures (T) of 22 to 600°C, using stepped displacement rates (v) from 0.3 to 100 μm/s. The gouges are characterized by a coefficient of friction (μ) of 0.2-0.3 at T ≤ 400°C and 0.3-0.4 at 500-600°C, while (a-b) values showed positive values for nearly all conditions tested, except at 300°C. Microstructures of gouges sheared at T ≤ 300°C show evidence for widespread comminution, compared with a lower porosity at 600°C. Experiments using a stack of single crystal sheets showed μ ≤ 0.008 at low displacements (<3 mm) followed by hardening, while microstructures are suggestive of slip along (001), folding and tear of cleavage planes, and gouge production. Our results have important implications for the mechanisms controlling megathrust fault slip under greenschist facies conditions in a subduction zone and shed new light on the strain accommodation mechanisms within sheared gouges versus single crystals composed of phyllosilicates.

The effect in mice of the molecular weight of polyethyleneglycol on prolonging the circulation time of large unilamellar liposomes (LUVs) was examined using four different distearoyl N-(monomethoxy polyethyleneglycol succinyl) phosphatidylethanolamines (DSPE-PEGs). The molecular weights tested were 1000, 2000, 5000 and 12000. Incorporation of 6 mol% of DSPE-PEG in LUV composed of distearoylphosphatidylcholine (DSPC) / cholesterol (CH) (1:1 in molar ratio) increased the blood circulation half-life significantly more than those without DSPE-PEG derivatives. DSPE-PEGs with molecular weights of 1000 and 2000 prolonged the circulation time of liposomes more than other DSPE-PEGs with higher molecular weights, such as 5000 and 12000. Their effects are also higher than ganglioside GM1, a well described glycolipid with this effect. DSPC/CH LUV-incorporated DSPE-PEG with a molecular weight of 2000 displayed a high concentration in the blood, approximately 40% of the dose, 6 h after the injection.