This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-Omethyl-1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.
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