Toxic epidermal necrolysis (TEN) is a very rare drug reaction associated with a high mortality rate. This condition warrants prompt recognition, diagnosis and treatment. Only one case report of TEN that was possibly induced by ritodrine hydrochloride, a tocolytic agent, was found in English literature. Here, we report the case of a 26-year-old pregnant woman who was suspected with TEN following the intravenous administration of ritodrine hydrochloride in the 35(th) week of gestation. An emergency cesarean section was performed because the labor pains caused systemic intolerable haphalgesia. After the surgery, intensive dermatological treatment commenced, which helped her recover from the serious condition. The result of the drug-induced lymphocyte stimulation test for ritodrine hydrochloride was positive. When a skin eruption appears during the administration of ritodrine, we must consider the benefits as well as the risks of continuous use of tocolytic agents because there is a risk of Stevens-Johnson syndrome or TEN.

Intrauterine growth restriction (IUGR) is one of the clinically important conditions to pay full attention to the fetus in womb. However, the process in diagnosing IUGR in daily clinical medicine has not been clarified. In research fields, most studies have been carried out from a retrospective point of view. In other words, the clinical data analysis was done by using the cases delivered as light for date (LFD). As long as the IUGR is not equal to LFD, the prospective point of view for diagnosing IUGR is required in clinical medicine. In this paper, we discussed how to predict and diagnose presumable growth retardation. Usually, ultrasound measurement and fetal weight estimation are used for diagnosis. We introduce one of the promising ways of standardizing fetal growth expressed by the ''deviation'' from the mean value. Growth velocity was also standardized by means of calculating the index of the deviation trend divided by gestational weeks.

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