Although the underlying mechanisms of pelvic organ prolapse (POP) remain unknown, disruption of elastic fiber metabolism within the vaginal wall extracellular matrix (ECM) has been highly implicated. It has been hypothesized that elastic fiber fragmentation correlates to decreased structural integrity and increased risk of prolapse; however, the mechanisms by which elastic fiber damage may contribute to prolapse are poorly understood. Furthermore, the role of elastic fibers in normal vaginal wall mechanics has not been fully ascertained. Therefore, the objective of this study is to investigate the contribution of elastic fibers to murine vaginal wall mechanics. Vaginal tissue from C57BL/6 female mice was mechanically tested using biaxial extension–inflation protocols before and after intraluminal exposure to elastase. Elastase digestion induced marked changes in the vaginal geometry, and biaxial mechanical properties, suggesting that elastic fibers may play an important role in vaginal wall mechanical function. Additionally, a constitutive model that considered two diagonal families of collagen fibers with a slight preference toward the circumferential direction described the data reasonably well before and after digestion. The present findings may be important to determine the underlying structural and mechanical mechanisms of POP, and aid in the development of growth and remodeling models for improved assessment and prediction of changes in structure–function relationships with prolapse development.

Tendon injuries are common to all ages. Injured tendons typically do not recover full functionality. The amount and organization of tendon constituents dictate their mechanical properties. The impact of changes in these constituents during (patho)physiologic processes (e.g., aging and healing) are not fully understood. Toward this end, microstructurally motivated strain energy functions (SEFs) offer insight into underlying mechanisms of age-dependent healing. Several SEFs have been adapted for tendon; however, most are phenomenological. Therefore, the aims of this study are: (1) evaluate the descriptive capability of SEFs in age-dependent murine patellar tendon healing and (2) identify a SEF for implementation in a growth and remodeling (G&R) model. To accomplish these aims, models were fitted to patellar tendon tensile data from multiple age groups and post-injury timepoints. Model sensitivity to parameters and the determinability of the parameters were assessed. A two-way analysis of variance was used to identify changes in parameters and the feasibility of implementing each model into a G&R model is discussed. The evaluated SEFs exhibited adequate descriptive capability. Parameter determinability and sensitivity analysis, however, highlighted the need for additional data to inform and validate the models to increase physiologic relevance and enable G&R model formulation to determine underlying mechanisms of age-dependent healing. This work, as a first, evaluated changes in tendon mechanical properties both as functions of age and injury in an age-dependent manner using microstructurally motivated models, highlights inherent dependencies between parameters of widely used hyperelastic models, and identified unique post-injury behavior by the aging group compared to the mature and aged groups.

No abstract

This paper presents the results of a pilot study comparing the use of continuum and non-continuum fluid dynamics to predict infrasound attenuation in the rarefied lower thermosphere. The continuum approach is embodied by the Navier-Stokes equations, while the non-continuum method is implemented via the Burnett equations [Proc. London Math. Soc. 39, 385-430 (1935); 40, 382-435 (1936)]. In the Burnett framework, the coupling between stress tensor and heat flux affects the dispersion equation, leading to an attenuation coefficient smaller than its Navier-Stokes counterpart by amounts of order 0.1 dB/km at 0.1 Hz, 10 dB/km at 1 Hz, and 100 dB/km at 10 Hz. It has been observed that many measured thermospheric arrivals are stronger than current predictions based on continuum mechanics. In this context, the consistently smaller Burnett-based absorption is cautiously encouraging.

No abstract