Po.001) and those reporting regular exercise (2 vs 20%, P 5.04) were statistically more likely to increase vitamin D intake during the 1-year study.
DISCUSSIONVitamin D is a safe, inexpensive strategy to reduce falls and associated medical costs. This study showed that older fallers have a low rate of meeting the vitamin D RAI, especially men, older individuals, those without prior fracture, and those not taking calcium supplements. Patients and providers need greater education on the importance of vitamin D for prevention of falls and fractures. Written instructions and regular telephone follow-up appear to increase vitamin D intake in elderly fallers. This finding, if verified in additional studies, may prove an effective public health strategy to decrease falls in older adults.
In 7 myotonic dystrophy (MyD) cases of 35- to 56-year old and 18 non-neurological age-matched controls paraffin-embedded temporal lobe sections were stained by the modified Bielschowsky method to count neurofibrillary tangles (NFTs) and senile plaques (SPs). In the parahippocampal gyrus, NFTs were observed in all the MyD cases; a few in the youngest, with an increase in number with age to the abundant appearance in the 4 cases in their 50s. The eldest also had many NFTs in the hippocampus. By contrast, the control subjects had, if any, only a few NFTs in the hippocampus and the parahippocampal gyrus. No SPs were observed in any MyD or control case. Thus, it was found that in MyD NFTs appear, unaccompanied by SPs, at an abnormally early age in the parahippocampal gyrus, with a rapid age-related increase in their number. This neuronal change may belong to the progeric features observed in this condition.
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