Amyloid A amyloidosis secondary to chronic inflammation involves systemic organs and tissues, including the gastrointestinal tract. In the present case, massive amyloid deposit caused gastric perforation. IgM co‐deposition in the glomeruli was another finding of note.
An 82-year-old man, suffering abscess secondary to femoral prosthesis
replacement, complained of intractable watery diarrhea and melena.
Autopsy disclosed 12 mm-sized perforation at the gastric prepylorus and
purulent peritonitis. Amyloid A was deposited in systemic organs and
tissues, including the site of gastric perforation. IgM was co-deposited
in the glomeruli.
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