The roles of active oxygen, lipid peroxidation, and the antioxidative defence mechanism in gastric mucosal injury induced by treatment with indomethacin in rats were investigated. The The present study was undertaken in rats to measure changes in lipid peroxides and antioxidants in serum samples and gastric mucosa after administration of indomethacin. Also, we investigated the effects of a superoxide radical scavenger (superoxide dismutase (SOD)), a hydrogen peroxide scavenger (catalase), and a hydroxyl radical scavenger (dimethylsulphoxide (DMSO)) on gastric mucosal injury and lipid peroxide formation induced by giving indomethacin to rats, and the effects ofa combination of SOD and catalase on indomethacin induced changes in antioxidants.

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