Herein, we disclose an efficient
ruthenium-catalyzed C–H
functionalization of 2-arylbenzimidazoles/2-arylimidazoles with iodonium
ylides leading to substituted tetracyclic and pentacyclic bridgehead
N-heterocycles, wherein iodonium ylide acts as a carbene precursor.
For the first time, iodonium ylide proceeds through a Ru–carbenoid
intermediate. Further, the synthetic utility of this protocol was
successfully shown for gram-scale synthesis and useful synthetic transformations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.