We investigate the existence of action for both the electric and magnetic sectors of Galilean Electrodynamics using Helmholtz conditions. We prove the existence of unique action in magnetic limit with the addition of a scalar field in the system. The check also implies the non existence of action in the electric sector of Galilean electrodynamics. Dirac constraint analysis of the theory reveals that there are no local degrees of freedom in the system. Further, the theory enjoys a reduced but an infinite dimensional subalgebra of Galilean conformal symmetry algebra as global symmetries. The full Galilean conformal algebra however is realized as canonical symmetries on the phase space. The corresponding algebra of Hamilton functions acquire a state dependent central charge.

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Background Rheumatoid arthritis (RA) is a systemic autoimmune disease. The combination therapy of methotrexate (MTX) and Janus kinase inhibitor (JAKi) is commonly used. Patients with RA are at increased risk of malignancy, however, it remains unclear whether the combination therapy is associated with a higher risk. Objective To assess the malignancy risk among patients with RA receiving combination therapy of JAKi and MTX compared to MTX alone. Methods PubMed, Cochrane and Embase were thoroughly searched for randomized controlled trials (RCTs) in patients with RA receiving JAKi and MTX, from inception to July 2020. Primary endpoints were malignancy events, Non melanomatous skin cancer (NMSC) and malignancy excluding NMSC and secondary endpoints were serious adverse events (SAE), deaths. Risk ratio (RR) and 95% CI were calculated using the Mantel–Haenszel random-effect method. Results 659 publications were screened and 13 RCTs with a total of 6911 patients were included in the analysis. There was no statistically significant difference in malignancy [RR = 1.42; 95% CI (0.59, 3.41)], neither NMSC [RR = 1.44 (0.36, 5.76)] nor malignancies excluding NMSC [RR = 1.12 (0.40, 3.13)]. No statistically significant difference between the two groups for SAE [RR = 1.15 (0.90, 1.47)] and deaths [RR = 1.99 (0.75, 5.27)] was found. Conclusion The adjunction of JAKi to MTX is not associated with an increased risk of malignancy when compared to MTX alone. There is no increased risk of SAE and deaths when compared to MTX alone in patients with RA.

Erythema multiforme (EM) is an acute, immune-mediated condition which affects the skin and mucous membranes. EM is a type 4 hypersensitivity reaction typically mediated by cytotoxic T lymphocytes. It is usually a self limiting, transient, inflammatory disease that spontaneously resolves within weeks without major sequelae. However, occasionally patients might have frequent recurrences, persistent disease or serious complications like fluid and electrolyte abnormalities. The most common triggers are infection followed by medications. Here we present the case of an 81-year-old female who came in with worsening lip and tongue swelling associated with a rash and was diagnosed with EM major due to naproxen.

We construct an [Formula: see text] supersymmetric gauge theory in Lifshitz space–time. Starting with [Formula: see text] supersymmetric Lagrangian, we introduce an additional [Formula: see text] symmetry between specific component fields. The resultant Lagrangian is shown to have an extra set of supersymmetry, thus realizing an on-shell [Formula: see text] supersymmetric gauge theory. Just as in the case of [Formula: see text], the superderivatives and superfields involved contain higher-order derivatives of spatial coordinates. The constructed [Formula: see text] supersymmetric Lagrangian has both vector multiplet and hypermultiplet.