Akhauri Yash Sinha scite author profile

Background: Mycobacteria down-regulates class II transactivator (CIITA)/MHC-II expression and antigen presentation. Results: During Mycobacterium bovis BCG infection, iNOS/NO responsive KLF4 induces EZH2 and miR-150 functions to regulate CIITA expression and thus antigen presentation. Conclusion: CIITA/MHC-II down-regulation by mycobacteria involves NOTCH/iNOS/NO/KLF4 signaling cross-talk and functions. Significance: Identification of novel regulators of host-mycobacteria interactions provides promising therapeutic potential.

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SOCS3 expression induced by PIM2 requires PKC and PI3K signaling

Narayana

Bansal

Sinha

et al. 2009

Molecular Immunology

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Akhauri Yash Sinha

Src Homology 3-interacting Domain of Rv1917c of Mycobacterium tuberculosis Induces Selective Maturation of Human Dendritic Cells by Regulating PI3K-MAPK-NF-κB Signaling and Drives Th2 Immune Responses

Nitric Oxide and KLF4 Protein Epigenetically Modify Class II Transactivator to Repress Major Histocompatibility Complex II Expression during Mycobacterium bovis Bacillus Calmette-Guérin Infection

SOCS3 expression induced by PIM2 requires PKC and PI3K signaling

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