e e ects of oral isotretinoin (13-Cis retinoic acid) on the inner ear: A prospective clinical study AbstractPurpose: e purpose of this study was to investigate the e ect of oral isotretinoin, a drug used in the treatment of acne vulgaris, on hearing function determined by serial audiology examinations.Methods: Forty patients with acne vulgaris were included in this study. Nine patients were excluded from the study because of inconsistent follow-up. e hearing of each participant was tested with pure tone audiometry and transient evoked autoacoustic emissions before and two and four weeks a er treatment with isotretinoin (0.3-0.6 mg/kg/day) in the remaining 31 patients (62 ears).Results: e di erences between the mean values of the pre-treatment and post-treatment pure tone hearing thresholds at 1000, 2000, 4000 and 6000 Hz frequencies were statistically signi cant (p<0.05), but there was no signi cant di erence between the pretreatment and post-treatment values at 250 and 500 Hz frequencies (p>0.05). e di erence between the pre-treatment and post-treatment signal-noise ratio values of the transient evoked autoacoustic emissions was not signi cantly di erent (p>0.05). Conclusion:Our results suggest that the use of isotretinoin may cause bilateral hearing threshold changes. Further animal and human studies are required to investigate and characterize isotretinoin-induced neurophysiological alterations in hearing.
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