Apoptosis Inducing Factor protein has a dual role depending on its localization in mitochondrion (energy production) and nucleus
(induces apoptosis). Cell damage transports this protein to nucleus which otherwise favors mitochondrion. The alteration of Nuclear
Localisation Signal tags could aid nuclear translocation. In this study, apoptosis inducing factor protein (AIF) was conjugated with
strong NLS tags and its binding affinity with Importin was studied using in silico approaches such as molecular modeling and
docking. This aims to improve the docking affinity of the AIF-Importin complex thus allowing for nuclear translocation, in order to
induce caspase-independent apoptosis of the cell.
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