PurposeChoroidal circulation hemodynamics in eyes with leukemia has not been quantitatively examined yet. We quantitatively examined changes in choroidal blood flow velocity and choroidal thickness at the macula by using laser speckle flowgraphy (LSFG) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with leukemic retinopathy.ObservationsA 15-year-old boy presented with sudden central vision loss of his right eye. The patient's best-corrected visual acuity was 0.09 OD and 1.2 OS. Funduscopy revealed a sub-inner limiting membrane hemorrhage at the macula, intra-retinal hemorrhages with Roth spots, and dilatation and tortuosity of retinal veins OU. Leukocytosis with the Philadelphia chromosome was found in the peripheral blood, which led to a diagnosis of retinopathy associated with chronic myeloid leukemia. Retinal hemorrhages resolved after chemotherapy. Macular mean blur rates on LSFG increased by 24–38% OD and 13–26% OS, while macular choroidal thicknesses on EDI-OCT decreased by 7–60 μm OD and 8–46 μm OS during the 3-month follow-up period after the start of treatment.Conclusion and importanceThese results suggest that choroidal blood flow velocity decreased and choroidal thickness increased sub-clinically in the acute stage of a patient with leukemic retinopathy. LSFG and EDI-OCT may be useful to non-invasively evaluate the activity of choroidal involvement in leukemic retinopathy.
Purpose To evaluate sequential changes in choroidal thickness at the affected area in patients with acute zonal occult outer retinopathy (AZOOR). Methods This retrospective observational case series included 14 affected eyes and 6 unaffected fellow eyes from 10 AZOOR patients with impaired macular area. Using enhanced depth imaging optical coherence tomography, choroidal thicknesses at the subfovea and at nasal and temporal sites 1000 μm away from the fovea were manually measured at baseline and 3 and 6 months thereafter. Changes in the choroidal thicknesses and the average threshold at the affected area on Humphrey perimetry were compared during the 6-month follow-up. Results In AZOOR eyes, the average threshold at the affected area significantly increased over time, while outer retinal structure ameliorated. The mean choroidal thicknesses at all the sites measured significantly decreased at 3 and 6 months compared with baseline values in AZOOR eyes, but not in fellow eyes. There was an inverse correlation between the changing rates of the average threshold and the subfoveal choroidal thickness at 6 months from baseline. Conclusion The current data suggest that choroidal thickness at AZOOR-affected area significantly decreased with regression of AZOOR and this anatomical change correlated with the functional recovery.
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