In this study, the effect of different concentration of the Aluminium oxide-based nanofluid on the performance of Solar Desalination system was discussed. The Aluminium Oxide was used in different concentrations 1%, 2% and 6% on weight basis. The flow rate was also varied and its effect on the system efficiency was discussed. The nanofluid was compared with the water and there was improvement occurred in the efficiency during variation of incident radiation. With an increase in the concentration of Aluminium oxide nanoparticles, improvement in the efficiency was attained. More efficiency was attained at 6% nanoparticles addition with compared to 1% and 2%. With an increase in mass flow rate of the fluid, the nanofluid also showed better performance in terms of improvement in the efficiency.