DNA-binding proteins (DBPs) have crucial biotic activities including DNA replication, recombination, and transcription. DBPs are highly concerned with chronic diseases and are used in the manufacturing of antibiotics and steroids. A series of predictors were established to identify DBPs. However, researchers are still working to further enhance the identification of DBPs. This research designed a novel predictor to identify DBPs more accurately. The features from the sequences are transformed by F-PSSM (Filtered position-specific scoring matrix), PSSM-DPC (Position specific scoring matrix-dipeptide composition), and R-PSSM (Reduced position-specific scoring matrix). To eliminate the noisy attributes, we extended DWT (discrete wavelet transform) to F-PSSM, PSSM-DPC, and R-PSSM and introduced three novel descriptors, namely, F-PSSM-DWT, PSSM-DPC-DWT, and R-PSSM-DWT. Onward, the training of the four models were performed using LiXGB (Light eXtreme gradient boosting), XGB (eXtreme gradient boosting, ERT (extremely randomized trees), and Adaboost. LiXGB with R-PSSM-DWT has attained 6.55% higher accuracy on training and 5.93% on testing dataset than the best existing predictors. The results reveal the excellent performance of our novel predictor over the past studies. DBP-iDWT would be fruitful for establishing more operative therapeutic strategies for fatal disease treatment.
The information technology era or the third industrial revolution began around the 1960s; has changed the ways we live, work, and play; and brought substantial challenges that include loss of privacy, fake news, digital divides, and significant information security risks. With billions of connections and systems, security vulnerabilities are abundant including the opportunity for criminals to exploit any gaps that present themselves. Eventually, we'll need a groundbreaking technology to gain the upper hand against these threats. Protecting data, systems, and networks assumed a more specific term: cybersecurity. The goal of cybersecurity today is to protect information while it's at rest and in motion. One of the most interesting ways to deliver hidden information is through steganographic technique.
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