In this study, the gravimetric method was taken to measure the solubility of the sarafloxacin hydrochloride under atmospheric pressure in methanol, isopropanol, ethanol, 1-butanol, acetonitrile, n-hexane, ethyl acetate, and N,Ndimethylformamide as well as in the (ethyl acetate + acetonitrile), (methanol + nhexane), and (ethyl acetate + n-hexane) mixtures from 278.15 to 333.15 K. The solubility of sarafloxacin hydrochloride increased with increasing temperature in all the solvents. The solid−liquid solubility equilibrium data in the pure and mixed solvents were in apparent agreement with the solubility predicted by the modified Apelblat model, Buchowski−Ksiazaczak λh model, Redlich−Kister (CNIBS/R-K) model, and Jouyban−Acree model. However, the Redlich−Kister (CNIBS/R-K) model best simulated the experimental solubility results.
In the present study, we focused on the
solubility of 2-chloromethyl-4-methylquinazoline. By the gravimetric
method, the solubility of 2-chloromethyl-4-methylquinazoline was measured
in cyclohexane, n-hexane, acetonitrile, tetrahydrofuran,
acetone, ethyl acetate, n-propanol, ethanol, isopropanol,
and butyl alcohol and in (s) and (cyclohexane + ethyl
acetate) binary solvent mixtures from 281.15 to 331.15 K under atmospheric
pressure. For all solubility data processing, we used the modified
Apelblat model and the Buchowski–Ksiazaczak λh model to fit. For the solubility data of (n-hexane + acetone) and (cyclohexane + ethyl acetate) binary solvent
mixtures, two binary solvent fitting models [combined nearly ideal
binary solvent/Redlich–Kister (CNIBS/R–K) model and
Jouyban–Acree model] and the modified Apelblat model were used
to fit. According to the fitting results, it could be seen that the
modified Apelblat model had a good correlation with the solubility
data of 2-chloromethyl-4-methylquinazoline in both pure and binary
solvent systems. The experimental data showed that n-hexane or cyclohexane could be used as effective antisolvents.
In the present study,
the solubility properties of 3-bromo-2-methyl benzoic acid were studied
by the gravimetric method under atmospheric pressure. In this experiment,
we chose the following eight pure solvents and three binary solvent
mixtures: Tetrahydrofuran, N,N-dimethylformamide,
methanol, ethyl acetate, ethanol, acetonitrile, water, cyclohexane,
(water + N,N-dimethylformamide),
(ethyl acetate + Tetrahydrofuran), and (acetonitrile + N,N-dimethylformamide), respectively. The experimental
temperature ranged from 278.15 to 328.15 K. The solubility data of
3-bromo-2-methyl benzoic acid in different pure solvents were fitted
by the modified Apelblat model and the Buchowski–Ksiazaczak
λh model. For the solubility data of 3-bromo-2-methyl
benzoic acid in the three groups of binary solvent mixtures, two binary
solvents- solvent-fitting models (combined nearly ideal binary solvent/Redlich–Kister
(CNIBS/R–K) model and Jouyban–Acree model) and the modified
Apelblat model- were used. By comparing the fitting results of each
model, it could be seen that as long as the initial component was
determined, the modified Apelblat model had a better correlation in
both pure solvents and binary solvent mixtures. The experimental data
showed that water, acetonitrile, or cyclohexane could be used as effective
antisolvents of 3-bromo-2-methyl benzoic acid.
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