No abstract

Background/Aims: The aim of this study was to evaluate the effect and mechanisms of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on immune responses in murine colitis. Methods: Mice with dextran sulfate sodium (DSS)-induced colitis were injected intraperitoneally with hUC-MSCs or human bone marrow-derived MSCs. The cytokine levels from lamina propria mononuclear cells (LPMCs) and colon tissue were measured using ELISA. Treg and Th17 cells were analyzed using flow cytometry. The proliferation of LPMCs was assessed using Cell Counting Kit-8. Results: hUC-MSCs ameliorate DSS-induced colitis via the downregulation of colon inflammatory responses. Furthermore, hUC-MSCs adjusted modulation of Treg/Th17 cells in the spleen and mesenteric lymph nodes. hUC-MSCs also inhibited LPMCs in vitro.Conclusion: hUC-MSCs may be an alternative source of stem cells and are worthy of study in long-term clinical trials.

Based on the fundamental results on MDS self-dual codes over finite fields constructed via generalized Reed-Solomon codes [9] and extended generalized Reed-Solomon codes [15], many series of MDS self-dual codes with different length have been obtained recently by a variety of constructions and individual computations. In this paper, we present an unified approach to get several previous results with concise statements and simplified proofs, and some new constructions on MDS self-dual codes. In the conclusion section we raise two open problems.2010 Mathematics Subject Classification. 11T06, 11T55.

AS patients investigated in this study exhibited BID. There were significant relationships between the BIDQ, disease and psychological variables, and QOL. Disease status, BID, and anxiety and depression indicated a poor QOL.