Rheumatoid arthritis is the inflammatory disease affecting the joints and imposes significant burden among the individuals. Oxidative stress is one of the major mechanisms involved in the progression of arthritis. It is postulated that inflammation and secretion of various inflammatory cytokines also plays pivotal role in rheumatoid arthritis. Tridax procumbens (Asteraceae) is one of the potent herb and possess various biological actions. So, the present study was carried out to evaluate the protective role of Tridax procumbens in a murine model of complete Freund's adjuvant (CFA) provoked arthritis. The rats were made arthritic by injecting 0.1ml CFA into rat hind paw by intradermal route. Tridax procumbens methanolic extract (200 and 400 mg/kg, b.wt) were administered orally daily for 28 days after induction of arthritis. The anti arthritic effect was evaluated by, alterations in paw volume and body weight, changes in hematological parameters, increased lipid peroxidation and decreased antioxidants (SOD, CAT, GPx and GSH) due to arthritis. Treatment with Tridax procumbens significantly reduced the paw volume and increased the body weight in arthritic rats. Further, treatment with Tridax procumbens significantly increased the RBC and hemoglobin and decreased the WBC and ESR level as compared to the arthritic rats. The antioxidant levels were significantly increased in arthritic rats after treatment with extracts. Thus the anti-arthritic potential of Tridax procumbens might be mediated through antioxidant and anti-inflammatory effect of the extracts
The current study was undertaken to evaluate the preclinical efficacy of methanolic extract of Tagetes erecta (METE) and methanolic extract of Tridax procumbens (METP) against Isoniazid and Rifampicin (INH-RIF) induced hepatic injury. Animals were randomly divided into seven groups, vehicle (control) or INH-RIF (50 mg/kg, i.p.), METE (200 and 400mg/kg, p.o.), METP (200 and 400mg/kg, p.o.) and standard silymarin for 28 days. INH-RIF intoxicated rats displayed significant (p<0.05) elevation in serum hepatic markers, lipid peroxidation and decrease in antioxidants like SOD, CAT, Gpx and GSH in liver tissue. Treatment with METE & METP (200 and 400 mg/kg, p.o.) restored the altered biochemical level to normalcy. Thus, the outcome of the study reveals that METE & METP showed promising hepatoprotective activity in INH-RIF induced hepatic damage mediated by its membrane stabilizing and antioxidant effect. All the methanolic plant extracts produce significant hepatoprotective activity against drug induced hepatic injury.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.