Our results indicate that some changes may occur on the hematic and biochemical analytes affecting the RBC deformability features. Neonates with CH have the worst rEI initially, but they reached the indices of the healthy infants thanks to L-thyroxin treatment. Also, their OF features have been improved by L-thyroxin.
People with existing health problems or reduced fitness may feel effects at a much lower altitudes than those who are more physically able. On the other hand living at higher altitudes is different than visiting. A number of studies describe many hematologic changes at extremely high altitudes. However, little information is known about the effect of long‐term living at mid‐altitude on hemorheologic parameters. In this study, the changes of hemorheological properties were investigated on 2 groups of healthy people aged 18–46, who have been living at low (1300m) and mid (2300m) altitude at Erciyes Mountain in Kayseri. Blood samples were taken from the antecubital vein using EDTA as the anticoagulant. An aliquot of the whole blood was used to analyse routine hematological parameters. RBC, HGB and PCV values were higher at mid altitudes than those at low altitudes. However, there were no significant differences in MCV, MCH and MCHC as red cell indices between two groups. As rheological parameters, erythrocyte deformability and osmotic fragility values were lower for people who lived at mid altitude compared to low altitude but an increase was observed in RBC aggregation index. It is known that the hemorheological properties of red blood cell membrane may be changed under hypoxic conditions depend on different altitudes. As a result, these results contribute to the knowledge of the pathogenesis of high altitude disease and stress the significance of altered hemorheology as one of the mechanisms possibly involved in the vascular events observed high altitude conditions. Supported by ERU. The Scientific Research Coordination Unit (BAP). Project No: TOA‐11‐3320
Multiple Sclerosis is an autoimmune disease of the central nervous system. It is a demyelinating and neurodegenerative condition, however, changes in the vasculature can occur and play a role in the pathophysiology. Cardiac and vascular risk factors contribute to the disease severity. Understanding the occurring hemodynamic changes may potentially lead to improved diagnosis, better patient management, and prevention of disease progression. This paper discusses the hemodynamic impairment in multiple sclerosis focusing on both the cerebral and cervical regions and presents an up-to-date review of the literature.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.