Biology has become a data-intensive science. Recent technological advances in single-cell genomics have enabled the measurement of multiple facets of cellular state, producing datasets with millions of single-cell observations. While these data hold great promise for understanding molecular mechanisms in health and disease, analysis challenges arising from sparsity, technical and biological variability, and high dimensionality of the data hinder the derivation of such mechanistic insights. To promote the innovation of algorithms for analysis of multimodal single-cell data, we organized a competition at NeurIPS 2021 applying the Common Task Framework to multimodal single-cell data integration. For this competition we generated the first multimodal benchmarking dataset for single-cell biology and defined three tasks in this domain: prediction of missing modalities, aligning modalities, and learning a joint representation across modalities. We further specified evaluation metrics and developed a cloud-based algorithm evaluation pipeline. Using this setup, 280 competitors submitted over 2600 proposed solutions within a 3 month period, showcasing substantial innovation especially in the modality alignment task. Here, we present the results, describe trends of well performing approaches, and discuss challenges associated with running the competition.

This paper presents a new large-scale signer independent dataset for Kazakh-Russian Sign Language (KRSL) for the purposes of Sign Language Processing. We envision it to serve as a new benchmark dataset for performance evaluations of Continuous Sign Language Recognition (CSLR) and Translation (CSLT) tasks. The proposed FluentSigners-50 dataset consists of 173 sentences performed by 50 KRSL signers resulting in 43,250 video samples. Dataset contributors recorded videos in real-life settings on a wide variety of backgrounds using various devices such as smartphones and web cameras. Therefore, distance to the camera, camera angles and aspect ratio, video quality, and frame rates varied for each dataset contributor. Additionally, the proposed dataset contains a high degree of linguistic and inter-signer variability and thus is a better training set for recognizing a real-life sign language. FluentSigners-50 baseline is established using two state-of-the-art methods, Stochastic CSLR and TSPNet. To this end, we carefully prepared three benchmark train-test splits for models’ evaluations in terms of: signer independence, age independence, and unseen sentences. FluentSigners-50 is publicly available at https://krslproject.github.io/FluentSigners-50/