Show your best face: An achiral pyrimidine‐5‐carbaldehyde that forms an achiral crystal (${{{\rm P}\bar 1}}$) with enantiotopic (001) and (${{00\bar 1}}$) faces underwent enantioselective addition of iPr2Zn to the single exposed enantiotopic surface to give highly enantiomerically enriched S and R secondary alcohols (see scheme). The absolute configuration of the alcohol product correlated with the orientation of the prochiral aldehyde in the achiral crystal lattice.
Zeig deine beste Seite: Bei einem achiralen Pyrimidin‐5‐carbaldehyd, der einen achiralen Kristall (${{{\rm P}\bar 1}}$) mit enantiotopen (001)‐ und (${{00\bar 1}}$)‐Seiten bildet, addiert sich iPr2Zn enantioselektiv an die einzelne exponierte enantiotope Oberfläche unter Bildung hoch enantiomerenangereicherter sekundärer S‐ und R‐Alkohole (siehe Schema). Die Absolutkonfiguration des Alkoholprodukts korreliert mit der Ausrichtung des prochiralen Aldehyds im achiralen Kristallgitter.
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