Context: Aiming the effects of severity of diabetes mellitus on human placenta and the neonatal outcome, a quantitative study at the macroscopic level was designed. Material and Methods: Sixty post caesarean section human placentae were studied of which thirty were from mothers having established diabetes mellitus considered as EDM and thirty were from control mother having no diabetes mellitus. EDM mothers were treated with insulin. Venous plasma glucose level (fasting and 2 hours after breakfast) of the EDM mothers in 2nd and 3rd trimester were recorded and the mean of the values were calculated. Results: The values ranged from 5.93 to 10.10mmol/L and the mean was 7.28±0.99 m mol/L. The mothers having EDM were grouped according to the mean venous plasma glucose level. The mothers having a mean level up to 8.3 m mol/L and those having a level above 8.3 m mol/L were designated as the Low-EDM and High- EDM group respectively. Placental weight in Control, Low-EDM and High-EDM groups were 414.93±95.41, 403.83±68.53 gm and 446.33± 82.23gm respectively. The value showed lower mean value in Low-EDM group. The difference did not reach a significant level. The neonatal weight in Control, Low-EDM and High-EDM groups were 2958.33±537gm, 2997.91±540 gm and 3300.00±379 gm respectively. The weight of the neonates did show a tendency towards being heavier in EDM groups but did not reach the significant level. There was a significant positive correlation between the neonatal weight and placental weight in control and Low-EDM group. Key words: Established diabetes mellitus; Placenta; Neonates DOI: http://dx.doi.org/ 10.3329/bja.v9i1.8150 Bangladesh Journal of Anatomy January 2011, Vol. 9 No. 1 pp 53-58
Taking in mind the effects of diabetes mellitus of varying severity on human placenta and their implication on the well being of the fetus, a quantitative study at the macroscopic level was designed. Sixty post caesarean section human placentas were studied of which thirty were from mothers having insulin treated established diabetes mellitus (EDM) considered as EDM group and thirty were from control mother having no diabetes mellitus. The venous plasma glucose level (fasting and two hours after breakfast) of the diabetic mothers in second and third trimester were recorded and the mean of the values were calculated. The value ranged from 5.93 to 10.10 and the mean was 7.28±0.90. The two groups did not differ significantly from each other with age, weight, height, or parity of the mother or in gestational age. Parenchymal volume in control and EDM group were 300.14±75.43 and 309.25±61.64 respectively. The value showed higher mean value in EDM group. The differences did not reach a significant level. The neonatal weight in control and EDM group were 2.95±0.53 and 3.05±0.52 respectively. The neonate did show a tendency towards being heavier in EDM group, but no reached the significant level. There was a significant positive correlation between the neonatal weight and the parenchymal volume in control and EDM groups. Key words: Established Diabetes Mellitus, Placenta, Parenchyma, Neonates. doi: 10.3329/bja.v7i1.3025 Bangladesh Journal of Anatomy January 2009, Vol. 7 No. 1 pp. 45-48
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