ÖZET Anahtar sözcükler: anti-tüberküloz ilaçlar, BACTEC MGIT 960 sistemi, direnç, Mycobacterium tuberculosis kompleks SUMMARY Resistance Ratios of Mycobacterium tuberculosis Complex Strains Isolated in Erzurum Regional Tuberculosis Laboratory Against Major Antituberculosis Drugs Tuberculosis is an important health problem for many countries in the world, especially in the developing countries. The aim of this study is to determine resistance rates of Mycobacterium tuberculosis complex (MTC) strains isolated from various clinical specimens in our region against isoniazid (INH), rifampicin (RIF), streptomycin (SM) and ethambutol (ETM), which are primary anti-tuberculosis drugs.Between RIF and INH, was 3.33 %

In the study, 419 Mycobacterium tuberculosis complex strains, which were isolated from samples sent to the Regional Tuberculosis Laboratory in our city between 2015 and 2019 with suspected tuberculosis from Erzurum and surrounding cities were investigated. Material and Method: Our research is a retrospective crosssectional study and clinical samples sent to the Regional Public Health Laboratory with suspicion of Tuberculosis within a five-year period from January 2015 to December 2019 were first evaluated by using Ehrlich-Ziehl-Neelsen staining technique. The samples were then simultaneously inoculated into the automated culture system (BACTEC MGIT 960) with Löwenstein-Jensen medium. Sensitivity research was conducted for isoniazide (INH), rifampicin (RIF), streptomycin (STM) and ethambutol (ETM) antibiotics with BACTEC MGIT 960 system to samples defined by M. tuberculosis complex strains identification test (TBc ID) from reproduction positive tubes. Results: In our study, 337 (80.4%) of the 419 M. tuberculosis complex strains investigated in our study were susceptible to all major anti-TB drugs, while 82 (19.6%) were found to be resistant to at least one major anti-TB drug. The distribution of resistance ratios was INH (11.9%), STM (11.7%), RIF (4.1%), ETM (3.6%). Multi-drug resistant (MDR)-TB ratio (IZN+ RIF) was found to be (3.6%). Conclusions: In our study, in the strains in which resistance to anti-TB drugs was investigated, the highest drug resistance was determined for IZN. The lowest drug resistance was determined for ETM.