Toward drugs to treat neuronal damage. The design and synthesis of new, potent, large‐conductance, calcium‐activated potassium‐channel (BKCa) openers that show calcium‐independent activation in electrophysiological evaluations have been brought about through optimizing the structure of the benzofuroindole skeleton by comparison with a known BKCa‐channel opener (BMS‐204352; see scheme). These new channel openers might find therapeutic use in stroke, asthma, hypertension, convulsion, and traumatic brain injury.
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