Objective: Stroke in young patients is not common. The purpose of this study was to find out the risk factors of stroke in young adults in Bangladesh and to compare with different other studies. Methods: 85 young adult cases of stroke patients with the age ranging from 14 to 45 years, admitted in different medical units of Dhaka Medical College Hospital from January 2008 to July 2009, were studied. The risk factors for stroke and the distribution of stroke types were analyzed. Results: The specific age group (14-45 years old) included 6% of patients of all ages admitted for stroke. Among 85 patients, cerebral infarction was diagnosed in 52 patients (61%). Intracerebral hemorrhage (without trauma) was diagnosed in 25 patients (29.4%). Subarachnoid hemorrhage was found in 7 young patients (8.24%). The most common risk factors for ischemic stroke were hypertension (57.68%), hypercholesterolemia (38.46%), diabetes (34.61%), smoking (32.69%), premature atherosclerosis (11.54%). Regarding aetiology of cerebral infarction, the majority due to cardiogenic emboli (75%). The use of oral contraceptives, pregnancy, SLE, migraine and moya moya disease were infrequent causes of cerebral infarction. In ischemic stroke, the ratio of cardiogenic emboli & other factors were 3:1. The most common risk factors for hemorrhagic stroke were hypertension (63.63%), hypercholesterolemia (39.39%), diabetes (36.54%) & smoking (33.33%). Conclusion: Hypertension, Diabetes, tobacco smoking, premature atherosclerosis & rheumatic valvular heart disease are growing problems in the developing countries. According to our finding, identification & treatment of hypertension, dyslipidaemia, diabetes & rheumatic valvular heart disease & cessation of smoking are proper measures to prevent morbidity & mortality. Key words: Risk factors; stroke; young adult. DOI: 10.3329/jdmc.v18i2.6265 J Dhaka Med Coll. 2009; 18(2) : 95-99

Management of spontaneous intracerebral haematoma (SICH) is divided into two groups -medical and surgical interventions. Although surgical management is controversial, it can be life saving when patient is deteriorating. Surgical techniques varies from large craniotomy, burr hole aspiration, stereotactic & endoscopic evacuation of haematoma. Forty eight patient of SICH were treated surgically using keyhole craniectomy technique, small craniectomy of 2-2.5 cm diameter. Surgical outcome assessed by Glasgow Outcome Score (GOS). Post-operative CT scan was done in all cases. Good recovery was achieved in 2 cases (4%), moderate disability in 20 cases (42%), 5 patients remain in vegetative state. Good evacuation of haematoma was seen in 42 patients except 6 cases deteriorated by post-operative CT scan. Surgical evacuation of SICH through keyhole technique is minimally invasive, safe and can achieve desired result. Patient with a GCS > 9 prior to surgery demonstrate a better outcome with this minimally invasive method.

DOI: http://dx.doi.org/10.3329/medtoday.v23i2.13096 Medicine TODAY Vol.23(2) 2011 pp.63-66

The uniqueness of this research is to identify the dynamics of strategic objectives, strategic policies of the textile sector of Bangladesh in order to manage working capital to achieve profitability. Keywords:Working capital management; Profitability; Textile sector; Bangladesh IntroductionIn the current perspective of the competitive market short-term assets and liabilities are important components of total assets and need to be analyzed carefully at the side of long-term assets and liabilities. Management of this short-term assets and liabilities are subject to investigate warily from the time because working capital management plays a vital function for the firm's profitability and risk as well as its value [1]. According to Alavinasab and Davoudi [2], "Working capital includes all short term assets which company uses it in daily activities. Working capital is an indicator for measuring the liquidity which is defined as adequacy of cash for doing firm's obligations". Generally, all short term assets which company use in daily basis is included in working capital. In the field of financial management, working capital management is a very sensitive area [3]. Working capital management is also very important for the firm's success; hence companies are trying to maintain optimal levels of working capital. Companies are adopting methods for managing proper level in various components of working capital i.e., cash receivables, inventory and payables etc. [4]. According to Pike and Neale [5], companies with improper condition of liquidity cannot pay their bills on the maturity date, in contrast companies with proper situation of liquidity have adequate cash for the payment of their bills on the maturity date. To increase the shareholder's wealth and firm's profitability, planning and policies regarding working capital management should get higher priority so that it should be done on the basis of supply chain management [2].Similar to the other business sectors, efficient management of working capital is equally important for textile sector as well. Textile companies are dealing with accounts payables and accounts receivables routinely along with their day to day activities for purchasing raw materials and for selling products. But due to the lack of knowledge regarding the working capital and lack of management's ability to plan and control its components, textile companies are facing insolvency, in long run their performance is deteriorating and causing bankruptcy [2]. Both the practitioners and researchers have emphasized on efficient management of working capital to ensure better performance and AbstractManagement of short-term assets and liabilities play vital role in generating profit in business sector. In the light of that, textile sector from all over the world is also emphasizing on to maintain optimal working capital to generate more profit. Researchers and practitioners around the world have done lot of work on how to maintain working capital in optimal level. Similarly, in Bangladesh, textile sector h...

word count 207 Word count 3,917 Figures 6 2 Abstract Neuroblastoma (NB) is the most common paediatric solid cancer with high fatality, relapses and acquired resistance to drug therapy. The clinical challenge NB poses requires new therapeutic approaches to improve survival rates.The WNT signalling pathway is crucial in embryonic development but has also been reported to be dysregulated in glioblastoma, ovarian, breast and colorectal cancer.LGR5 is a receptor which potentiates the WNT/β-catenin signalling pathway, hence contributing to cancer stem cell proliferation and self-renewal.LGR5 has been reported to promote both development and survival of colorectal cancer and glioblastomas.Our previous study illustrated that LGR5 is associated with aggressiveness in NB cell lines established at different stages of treatment. Following these findings, we investigated whetherLGR5 is involved in acquired drug resistance via the WNT pathway in NB cell lines.Cell lines in this study have an acquired drug resistance to vincristine (VCR) or doxorubicin (DOX).In this study, we showed LGR5-LRP6 cooperation with enhanced expression of both proteins in SHSY5YrVCR, IMR32rDOX, IMR5rVCR and IMR5rDOX NB cell lines compared to paired parental cells. We also found elevated expression of β-catenin in cell lines with acquired drug resistance is indicative of β-catenin-dependent WNT signalling.This study warrants further investigation into the role of the WNT signalling pathway in acquired drug resistance.