Groundwater overexploitation is related to various environmental, economic, and social aspects that should be comprehensively addressed to support sustainable water supply globally. This is the first study to delineate the sustainable development goals (SDGs) associated with the groundwater management practices for minimizing the overexploitation episodes. Ten thematic maps of the hydrologic, geologic, and topographic layers for the Wadi El-Natrun basin, Egypt, were weighted by multi-criteria decision analysis (MCDA). The layers were integrated by geographic information system (GIS) to obtain an overall vulnerability map, showing a high validation accuracy with field measurements of piezometric water levels (R 2 : 0.87). Based on the sensitivity analysis, groundwater overexploitation was highly influenced by distance from the feeding fault (DFF), followed by the soil's hydraulic conductivity (HC) and land surface elevation (ELE). The western and southern zones of the basin were "Highly" vulnerable to groundwater overexploitation, assigning to the far DFF, low HC, and the dominance of upland plains, steep slopes, and elevated surface with an increased groundwater depth. The interaction between all thematic criteria and vulnerability indices showed strong correlations with SDGs and associated targets, regarding end poverty and hunger, provide safe and affordable water utilization, support economic growth, and protect land and water ecosystems. Defining the SDGs interlinkages would assist in sustainable water resource utilization, planning, and management worldwide, particularly in water-stressed areas.
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