In this work, we investigate the design of information-update systems, where incoming update packets are forwarded to a remote destination through multiple servers (each server can be viewed as a wireless channel). One important performance metric of these systems is the age-of-information or simply age, which is defined as the time elapsed since the freshest packet at the destination was generated. Recent studies on information-update systems have shown that the ageof-information can be reduced by intelligently dropping stale packets. However, packet dropping may not be appropriate in many applications, such as news and social updates, where users are interested in not just the latest updates, but also past news. Therefore, all packets may need to be successfully delivered. In this paper, we study how to optimize age-of-information without throughput loss. We consider a general scenario where incoming update packets do not necessarily arrive in the order of their generation times. We prove that a preemptive Last Generated First Served (LGFS) policy simultaneous optimizes the age, throughput, and delay performance in infinite buffer queueing systems. We also show age-optimality for the LGFS policy for any finite queue size. These results hold for arbitrary, including non-stationary, arrival processes. To the best of our knowledge, this paper presents the first optimal result on minimizing the age-of-information in communication networks with an external arrival process of information update packets.

Abstract-The problem of reducing the age-of-information has been extensively studied in the single-hop networks. In this paper, we minimize the age-of-information in general multihop networks. If the packet transmission times over the network links are exponentially distributed, we prove that a preemptive Last Generated First Served (LGFS) policy results in smaller age processes at all nodes of the network (in a stochastic ordering sense) than any other causal policy. In addition, for arbitrary general distributions of packet transmission times, the nonpreemptive LGFS policy is shown to minimize the age processes at all nodes of the network among all non-preemptive workconserving policies (again in a stochastic ordering sense). It is surprising that such simple policies can achieve optimality of the joint distribution of the age processes at all nodes even under arbitrary network topologies, as well as arbitrary packet generation and arrival times. These optimality results not only hold for the age processes, but also for any non-decreasing functional of the age processes.

In this paper, we investigate scheduling policies that minimize the age of information in single-hop queueing systems. We propose a Last-Generated, First-Serve (LGFS) scheduling policy, in which the packet with the earliest generation time is processed with the highest priority. If the service times are i.i.d. exponentially distributed, the preemptive LGFS policy is proven to be age-optimal in a stochastic ordering sense. If the service times are i.i.d. and satisfy a New-Better-than-Used (NBU) distributional property, the non-preemptive LGFS policy is shown to be within a constant gap from the optimum age performance. These age-optimality results are quite general: (i) They hold for arbitrary packet generation times and arrival times (including out-of-order packet arrivals), (ii) They hold for multi-server packet scheduling with the possibility of replicating a packet over multiple servers, (iii) They hold for minimizing not only the time-average age and mean peak age, but also for minimizing the age stochastic process and any non-decreasing functional of the age stochastic process. If the packet generation time is equal to packet arrival time, the LGFS policies reduce to the Last-Come, First-Serve (LCFS) policies. Hence, the age optimality results of LCFS-type policies are also established.

Information updates in multihop networks such as Internet of Things (IoT) and intelligent transportation systems have received significant recent attention. In this paper, we minimize the age of a single information flow in interference-free multihop networks. When preemption is allowed and the packet transmission times are exponentially distributed, we prove that a preemptive Last-Generated, First-Served (LGFS) policy results in smaller age processes across all nodes in the network than any other causal policy (in a stochastic ordering sense). In addition, for the class of New-Better-than-Used (NBU) distributions, we show that the non-preemptive LGFS policy is within a constant age gap from the optimum average age. In contrast, our numerical result shows that the preemptive LGFS policy can be very far from the optimum for some NBU transmission time distributions. Finally, when preemption is prohibited and the packet transmission times are arbitrarily distributed, the nonpreemptive LGFS policy is shown to minimize the age processes across all nodes in the network among all work-conserving policies (again in a stochastic ordering sense). Interestingly, these results hold under quite general conditions, including (i) arbitrary packet generation and arrival times, and (ii) for minimizing both the age processes in stochastic ordering and any non-decreasing functional of the age processes.

In this paper, we consider the problem of minimizing the age of information in a multi-source system, where samples are taken from multiple sources and sent to a destination via a channel with random delay. Due to interference, only one source can be scheduled at a time. We consider the problem of finding a decision policy that determines the sampling times and transmission order of the sources for minimizing the total average peak age (TaPA) and the total average age (TaA) of the sources. Our investigation of this problem results in an important separation principle: The optimal scheduling strategy and the optimal sampling strategy are independent of each other. In particular, we prove that, for any given sampling strategy, the Maximum Age First (MAF) scheduling strategy provides the best age performance among all scheduling strategies. This transforms our overall optimization problem into an optimal sampling problem, given that the decision policy follows the MAF scheduling strategy. While the zero-wait sampling strategy (in which a sample is generated once the channel becomes idle) is shown to be optimal for minimizing the TaPA, it does not always minimize the TaA. We use Dynamic Programming (DP) to investigate the optimal sampling problem for minimizing the TaA. Finally, we provide an approximate analysis of Bellman's equation to approximate the TaA-optimal sampling strategy by a water-filling solution which is shown to be very close to optimal through numerical evaluations.

No abstract

Objective:MicroRNA-155 (miRNA-155) resides within the B-cell integration cluster gene on chromosome 21. It can act either as an oncogene or as a tumor-suppressor gene, depending on the cell background in which miRNA-155 is performing its specific target gene controlling function. Therefore, the aim of this study was to investigate miRNA-155 expression in patients with B-cell non-Hodgkin lymphoma (NHL) and its relation to disease prognosis in diffuse large B-cell lymphoma (DLBCL) patients.Materials and Methods:Reverse transcription-polymerase chain reaction assay was performed to evaluate the expression levels of miRNA-155 in 84 patients with newly diagnosed B-cell NHL and 15 normal controls.Results:Compared with normal controls, miRNA-155 expression was significantly upregulated in patients. Moreover, higher levels of miRNA-155 were associated with the presence of B symptoms, involvement of extranodal sites, and high Eastern Cooperative Oncology Group (ECOG) score. Higher levels of miRNA-155 in DLBCL were associated with non-germinal B-cell-like type, the presence of B symptoms, involvement of extranodal sites, and higher International Prognostic Index (IPI) and ECOG scores. Only the high IPI score and high miRNA-155 expression indicated a higher risk of lower event-free survival using multivariate Cox regression analysis. Our data demonstrated that the expression of miRNA-155 was upregulated in newly diagnosed B-cell NHL patients. miRNA-155 is expressed at a lower level in GCB-subtype DLBCL. Low IPI score and miRNA-155 expression were predictors of longer event-free survival.Conclusion:Despite contradicting literature reports, the current findings suggest the potential value of miRNA-155 as a biomarker of prognosis and monitoring in B-cell NHL, and especially that of the DLBCL type.

CYP3A5*3 polymorphism was associated with imatinib efficacy while the SNP SLCO1B3 (T334G) was not associated with the response to imatinib treatment in Egyptian patients with CML in chronic phase. These results prompt us to explore the effect of CYP3A5*3 in CML patients taking imatinib in a larger scale study.