The importance of Schiff's bases is that they are used as anti-bacterial, tuberculosis, cancer and tumors, as well as their ability to capture metal ions. Schiff's bases play an important role in analytical and industrial chemistry as they are used to resist the corrosion of metals. Photolysis is not considered a degradation pathway for azo dyes. In order to extend the life of products dyed with azo dyes, it is necessary to ensure stability against microbial attack, and tests have shown that azo dyes degrade significantly in short-term tests under aerobic conditions. However, under anaerobic conditions, color change can be observed as a result of biodegradation .A general method for the synthesis of new Azo compound has been employed. Diazotization reaction between 2-amino pyrimidine and 2-amino-4-nitro phenol was used to produce Azo compound F1 [2-amino-4-nitro-6-(pyrimidin-2-yldiazenyl)phenol] then prepare two Azo-Shiff base derivatives by Aldol-condensation reaction of (F1) with p-N,N-dimethyl amino Benzaldehyde and Isatin to give (F2,F3).The research included biological screening as anti-bacterial for (F,F2,F3) and as anti-cancer for (F3) by using cell line type Hep G2. FT-IR,1H-NMR, 13C-NMR and two-dimensional(2D)HSQC spectroscopy was used to characterize these compounds.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.