Infection is a continuous problem in cancer patient especially in developing country. Multidrug-resistant gram negative bacteria are among the most frequent complication in immunocompromised cancer patients and pose the greatest risk to immunocompromised cancer patient. Our study aimed to carry out a retrospective study on Gram negative bacteria isolated from various clinical samples among cancer patient in Erbil city and analyze its epidemiology, antibiotics susceptibility pattern test and multi-drug resistance. A total of 588 samples were collected from eight sources (urine, stool,blood,abscess and wound swab, throat and tonsil swab, CSF, sputum and ear swab) from patient attending Nanakaly Hospital and from both male and female from Jun 2017 to November 2018. Only 83 cases had been identified as Gram negative bacteria isolates which isolated and identified by using macroscopically, microscopically, biochemical tests and Vitek 2 compact system . Also antibiotic susceptibility test were performed by Vitek 2 compact on fifteen antibiotics. Only eighty three Gram negative bacteria isolates isolated from 588 samples distribution according to their source of isolation in cancer patient, Our results showed that the highest percent of the isolates belong to genus E.coli 61(10.4%) followed by Klebsiella spp. 14(2.4%), Enterobactor spp. 6(1%), Acinetobactor spp. 1(0.2%) and Pseudomonas spp. 1(0.2%), urinary tract infection isolates are the most frequent in our study which is 56 (67.5%) followed by Respiratory tract infection 8 (9.6%),Blood stream infection 7 (8.4%), Gastrointestinal infection and Skin-wound infection 6 (7.2%),the highest percentage of E.coli was isolated from female samples 45(7.7%) while only 16(2.7%) from male and when performing antibiotics susceptibility test, bacteria showed highest resistance to Ceftriaxone and Amoxicillin 39(47%), followed by Ticarcillin-clavulanic acid 37(44.6%), Vancomycin 36(44.4%) and Doxycycline 34(40.96%) respectively,in contrast the highest effective antibiotics were Amikacin 81(97.6%), Gentamicin 80 (96.4%), Meropenem and Imipenem 79(95.2%), in which the highly resistance of E.coli in urine sample has been noticed to Ceftriaxone and Amoxicillin which are 24(54.5%) and in blood has been showed to Amoxicillin is 5(83.3%), followed by stool that has been noticed to Ticarcillin-clavulanic acid which is 3(60%) and in wound has been noticed to Ceftriaxone 4(66.7%), in contrast the highly sensitivity for E.coli in urine has been showed to Amikacin which is 43(97.7%), and in blood has been showed to Cefepime, Ertapenem, Gentamicin, Amikacin, Imipenem and Levofloxacin which are 6(100%), in stool has been noticed to Cefepime, Amoxicillin, Ertapenem, Gentamicin, Amikacin, Imipenim, Meropenem, Levofloxacin and Ciprofloxacin which are 5(100%) and for wound sample has been noticed to Gentamicin and Meropenem which are 6(100%).In general 72(86.7%) isolates of Gram negative bacteria were multidrug resistance to more than three antibiotics, in which urinary tract infection are the most fr...
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