Diabetes has become a serious global public health problem due to its high prevalence and mortality. Unfortunately, current anti-diabetic drugs are having some limitations and adverse effects. Therefore, searching for a new anti-diabetic agent is an urgent challenge. In this research, we examined the effectiveness of a traditional anti-diabetic polyherbal composed of Sesbania grandiflora seeds, Salacca zalacca leaves and Acalypha indica roots (2:1:1). The study was aimed to explore the anti-hyperglycemic effect of the polyherbal in STZ-induced diabetic mice and to investigate the immunomodulatory activity involved in the process of controlling hyperglycemia. Our results showed that the polyherbal water extract (150 mg.kgBW-1) could suppress blood glucose elevation and preserve pancreatic islet of diabetic mice. Moreover, the polyherbal treatment could normalize the relative amount of activated CD4 + CD62Land CD8 + CD62L-T cells. The polyherbal extract also stimulated the production of CD4 + CD25 + FoxP3 + regulatory T cells (Tregs) which is known to play an important role in diabetes control. In addition, polyherbal treatment also increased the relative amount of anti-inflammatory cytokines IL-10 and TGF-β. These results revealed that the polyherbal extract has an anti-hyperglycemic and immunomodulatory activity that may provide beneficial function in diabetes healing.
Abstract. Diabetes is one of the fastest growing diseases in the world: its prevalence is estimated to reach 642 million people, or one-tenth of adults will have diabetes by 2040. Traditional herbal exploration and investigation are needed in order to discover medicines that have potential anti-diabetic activity, with no or lower side effects than the medicines clinically used today. In this research, we investigated the anti-hyperglycemic activity of an aqueous decoction of Sesbania grandiflora seeds in streptozotocin-induced diabetic mice, and analyzed the immune responses that occurred during the counter balance process to reach blood glucose homeostasis. Our results revealed that administration of the aqueous decoction (2.5 g/kg BW) could lower the blood glucose levels of diabetic mice from an initial blood glucose level of 435 mg/dl to 213 mg/dl within 18 days of treatment. Analysis of inflammatory markers showed that there was no significant difference in the relative amounts of CD4 + CD62L -, CD8 + CD62L -, TNF-α or IFN-γ between the experimental groups, which revealed that there were no pro-inflammatory responses involved either in hyperglycemia or in the blood glucose lowering process. On the other hand, an increased amount of interleukin-10 in diabetic mice treated with an S. grandiflora seed decoction indicated a role for IL-10 in maintaining blood glucose homeostasis.
Tanaman Nilam (Pogostemon cablin Benth) merupakan salah satu jenis tanaman penghasil minyak atsiri. Dengan meningkatnya produksi minyak nilam, volume penyulingan minyak nilam semakin tinggi akan menyebabkan kuantitas limbah nilam pada industri penyulingan minyak nilam pun semakin banyak. Besarnya volume limbah hasil penyulingan minyak nilam seringkali menjadi masalah bagi pihak industri usaha penyulingan sendiri maupun lingkungan masyarakat di sekitarnya. Penelitian ini bertujuan untuk mengetahui komponen senyawa metabolit sekunder yang masih terkandung dalam limbah penyulingan minyak nilam. Ekstraksi limbah penyulingan dilakukan dengan menggunakan pelarut etanol 95 % selama 48 jam. Analisis fitokimia yang dilakukan menggunakan metode (Harborne, 1998) dan (Kokate, 2001). Hasil pengujian metabolit sekunder menunjukkan ekstrak nilam dari limbah penyulingan mengandung senyawa alkaloid, flavonoid, tanin, saponin dan steroid. Berdasarkan hasil penelitian yang dilakukan, dapat menjadi rujukan dilakukannya kajian bioaktivitas lanjutan pada ekstrak limbah padat penyulingan minyak nilam.
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