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Background: Thrombotic complications of COVID-19 are a worrisome aspect of the disease due to its high incidence in critically ill patients and poor clinical manifestations. The aim of this study was to determine the relationship between the effectiveness of heparin administration and complications of hypercoagulation in hospitalized patients with confirmed COVID-19.Method: This research was analytically observational. The study design used was a retrospective cohort approach of pre- and post-tests. This study used secondary data taken from medical records of inpatients with confirmed COVID-19 at Islamic Hospital Jakarta Sukapura. The total sampling technique was used. Result: There were 98 study subjects, with 35 patients receiving UFH and 63 patients receiving LMWH (fondaparinux). Most of the subjects were women (52%), with the most common age group being >60 years (30.6%). In the UFH group, the greatest decrease (0.01±0.5 g FEU/mL) was observed in 12 patients (34.3%). In the LMWH group (fondaparinux), the greatest decrease (0.01±0.5 g FEU/mL) was observed in 15 patients (23.8%). Additionally, there was no significant difference between UFH and fondaparinux (p 0.193) in hospitalized patients with confirmed COVID-19 for the period of August 2020 – August 2021. Most inpatients with confirmed COVID-19 at RSIJ Sukapura were aged 50-59 years and were women. Conclusion: There was a tendency toward increased D-dimer values, normal PT values, normal APTT values, and increased fibrinogen values in each COVID-19 patient, but there was no statistically significant relationship. There was also no significant relationship between the D-dimer and APTT parameters, whereas the PT parameter showed a significant relationship in confirmed COVID-19 inpatients.