Background Hamm is an Arabic word that is used to express suffering. Idioms of distress are communicated differently in different contexts and cultures. Understanding idioms of distress and symptoms can help in diagnosis and lead to socioculturally sensitive health care.
Introduction: A patient-derived orthotopic xenograft (PDOX) nude-mouse model and irrespective of genetic profile can help guiding our treatment in progressive and resistant Ewing Sarcoma (ES) patients progressed after Doxorubicin containing regimens.Patients and methods: In our study, the PDOX mice established model with ES were divided into two arms once tumor mass exceeded 60 mm3: (1) untreated control (2) irinotecan plus temozolomide (irinotecan: intra-peritoneal injection; temozolomide: orally, daily for 14 days). A similar study was carried out on patients from whom the graft was taken. We have collected data from 35 patients of ES: diagnosed, treated and progressed after the first line chemotherapy. Those patients received oral temozolomide 100mg/m² on days 1 through 5 plus IV irinotecan 10-20 mg/m²/day on days 1 through 5 and day 8 through 12 (repeated every 3-4 weeks). results: Irinotecan plus temozolomide was found to be an effective combination when compared to the untreated control (p = 0.022) in mice model where tumor shrinkage was observed on day 10. To assure these findings, we have conducted in part, a study employing both Temozolomide and irinotecan in patients resistant to Doxorubicin containing regimens and demonstrating EWS-ERG fusion and CDKN2A loss. However, the same protocol was used to the same patient where the graft was taken showing not complete concordance between the lab and real practice. conclusion:PDOX is a good model to test a library of drugs on. It shows to be a promising method in several studies and in ours as well. Studies demonstrated that the combination of temozolomide/irrinotecan is effective in ES patients in progression after Doxorubicin resistance.
Background Young people in the occupied Palestinian territory are facing considerable challenges that affect their wellbeing. As limited research on youth wellbeing in this region exists, this study aims to assess the prevalence of wellbeing and its determinants among youths in the occupied Palestinian territory. Methods We carried out a secondary data analysis of the Power2Youth cross-sectional survey, conducted between Oct 13, 2015 and Dec 31, 2015 in the occupied Palestinian territory. The sample consisted of 1353 youths aged 18-29 years (53.8% were female) living in the West Bank and the Gaza Strip. Bivariate and multivariate analyses were conducted with the WHO-5 Well-Being Index as the dependent variable and seven independent variables: demographic (age, sex, locality, and region), socioeconomic status (education and subjective economic situation scale), trust in people, personal freedom, political confidence, satisfaction with the quality of governance, and future outlook. Informed verbal consent was obtained from the participants. Findings The mean wellbeing score was 58•73 (SD 22•7). Age (β=−0•60, p=0•01) and being male were negatively associated with wellbeing, with male scores approximately three points lower than for females on the wellbeing scale (β=−2•80, p<0•05). By contrast, living in camp areas compared to urban areas (β=4•45, p<0•01), trust in people (β=1•92, p<0•001), personal freedom (β=2•02, p<0•001), satisfaction with the quality of governance (β=2•36, p<0•001), satisfaction with economic conditions (β=1•61, p<0•001) and positive future outlook (β=0•67, p<0•01) were all significantly positively associated with wellbeing. Interpretation The results underscore the impact of demographic, social, economic, and political circumstances on youth wellbeing in the occupied Palestinian territory, with trust in people, personal freedom, and satisfaction with economic conditions having the greatest impact. These variables and satisfaction with the quality of governance were found to have a significant positive association with youth wellbeing, highlighting the importance of the political domain. Finally, the positive association between outlook and wellbeing indicates that youths' future outlook can impact wellbeing in the present.
Background Young people in the occupied Palestinian territory face challenges-including economic, political, and social challenges-that hinder their wellbeing. It is therefore pertinent to understand the needs of the youth and the factors that determine their well-being. This study explores the understanding and definition of well-being from the perspective of Palestinian youths, and their views of the factors that influence wellbeing. Methods A qualitative investigation of twelve focus group discussions was carried out in 2017. The participants were Palestinian youths (aged 18-32 years) residing in the West Bank, including East Jerusalem, and the Gaza Strip. Participants were selected using snowball sampling, with the help of various community organisations, and youths' personal contacts. A total of 123 youths participated in the discussions, which were recorded and transcribed verbatim. Research team members coded the transcripts and then organized codes into key dimensions of life (ie, economic, political, social, and personal), and into themes within these dimensions. Ethics approval was obtained from Birzeit University. Informed verbal consent was obtained from all participants.
This study examined the experience of bereavement because of COVID-19 among the Arab minority in Israel, based on the two-track model of grief, using a qualitative approach. The data was collected in an in-depth interview with 34 participants representing the three religions in the Arab population in Israel, approximately 1 year after the loss occurred. The findings revealed that most participants reported returning to their previous function almost completely, exclusively in the field of work. However, they reported decreased social functioning and feelings of loneliness and sadness, and some reported manifestations of active and traumatic grief. Some findings may create a false impression that the mourners have gone through the loss process and returned to normal. However, the current study’s findings refute this conclusion, which requires appropriate treatment from health professionals.
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