The synthesis of 2-substituted thiazolo [3,2-b] [1,2,4]triazoles is accomplished copper-free, Pd-catalyzed Sonogashira reaction of 6-(iodomethyl)-2-methylthiazolo[3,2-b][1,2,4]triazole with terminal alkynes in DMF at 70°C. The coupling reaction of phenylacetylene and 4-ethynyltoluene gave the desired products in high yields. While, the Sonogashira reaction of alkynes such as 1-hexyne, 1-octyne, propargyl alcohols, and propargyl amines afforded the products in good yields.ChemistrySelect 2019, 4, 9238 -9240
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