The study aims to evaluate the effect of Tribulus terrestris and Andrographis paniculata on body weight, blood glucose, lipid profile and renal protective capability in alloxan induced type-1 diabetic mice. Six groups of five male Swiss Albino mice each, at four weeks of age were used in this experiment. Group-X were fed saline water and Group-Y with combined herbal formulation at a high dose (1 g/kg bwt) to asses toxicity .The remaining four groups were designated into healthy control, diabetic control , diabetic + Amaryl ® 800 µg/kg , Diabetic + Formulation 200 mg/kg bwt .The combined formulation improved body weight loss and lowered blood glucose levels significantly (P<0.001) compared to diabetic control group after 8 weeks of treatment. The total cholesterol and plasma triglyceride were decreased at a significant level (P<0.01) compared to diabetic control. However, High density lipoproteins (HDL) and Low density lipoproteins (LDL) levels remained unchanged by combined formulation compared to diabetic control. The combined formulation also lowered the plasma creatinine levels in the formulation treated group compared to diabetic control. Histo-pathological evaluation revealed that combined formulation partially improved renal glomerular sclerosis and hypertrophy, tubular damage and pancreatic β-cells damage. The combined herbal formulation may have antidiabetic and renal protective capability in alloxan induced type-1 diabetic mice.
The study was undertaken to investigate the antidiabetic effects of crystals derived from Stevia rebaudiana leaves in normal rats and alloxan induced diabetic mice. Normal rats were used to evaluate whether the stevia crystal have any adverse effects on body weight and blood glucose of healthy rats. The rats were divided into two groups (n=5); healthy control rats and stevia treated healthy rats (1 g/kg/day orally). To evaluate the antidiabetic effects of stevia crystal, mice were divided into five equal (n=5) groups; healthy control, diabetic control, stevia crystal @ 250 and 500 mg/kg bwt, and Amaryl ® @ 800 µg/kg daily to compare the efficacy. Alloxan monohydrate was injected in mice at a dose rate of 120 mg/kg intraperitoneally for diabetic induction. Result of the present study showed that stevia crystal at a high daily dose did not have any significant effect on body weight but it reduced blood glucose level non-significantly in healthy animal. The antidiabetic effects of stevia crystal was evaluated based on glucose lowering capacity, improvement of body weight loss, changes in lipid profile, and renal and pancreas protective capacity. Treatment with stevia crystal @500 mg/kg improved body weight loss and reduced blood glucose level significantly Original Research Article
Many medicinal plants are becoming increasingly popular for the treatment of various ailments, including diabetes, all around the world. This study was designed to elucidate the comparative efficacy of Tribulus terrestris, Andrographis paniculata, and Lagerstroemia speciosa on glucose intolerance, lipid profile, renal and pancreatic injury in alloxan induced type-1 diabetic mice. In this study, four-week-old male Swiss Albino mice were divided into six groups of five each. To assess toxicity, Group-X was given saline water, while Group-Y was given a combination herbal formulation at a high dose (1 g/kg bwt). No adverse effect of combined formula on body weight and blood glucose was observed in normal healthy mice. The other four groups were labeled as Group-A, healthy normal mice; Group-B, Diabetic mice; Group-C, Diabetic mice treated with Andrographis paniculata, Tribulus terristris @ 200 mg/kg and Lagerstroemia speciosa @ 0.5ml/animal; and Group-D, Diabetic mice treated with Amaryl®@ 800 g/kg bwt. The combined formulation improved body weight loss significantly (P<0.001) compared to diabetic control group after 8 weeks of treatment. Combined formulation and Amaryl® decreased non-significantly total cholesterol, plasma triglyceride and plasma creatinine level compared to diabetic control. However, HDL and LDL levels remained unchanged by the treatment. Consistent with these findings, histopathological evaluation revealed that combined formulation partially improved renal glomerular sclerosis and hypertrophy, tubular damage and pancreatic β-cells damage reflected its renal and pancreatic damage curative property. The obtained results suggest that combined use of Andrographis paniculata, Tribulus terrestris and Lagerstroemia speciosa as antidiabetic herbal formulation, synergizing its therapeutic value in treating hyperglycemia and diabetes related complications mainly renal and pancreatic injury.
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