This study covers factors influencing the adoption of electronic health (eHealth) technologies in Ghana. The study was designed as a quantitative survey with questionnaire as the main method of data gathering. A total of 1640 questionnaires were administered to users and potential users of eHealth technologies in both public and private healthcare centres in Ghana. The study concludes that institutional characteristics and healthcare manager characteristics have a high influence on eHealth adoption. However, factors related to performance expectancy and effort expectancy only have low influence on the adoption of eHealth devices and systems. Accordingly, the study makes recommendations to policymakers for improving eHealth adoption in the health sector.