BACKGROUNDA foreign body reaction (FBR) is a typical tissue response to a biomaterial that has been injected or implanted in human body tissue. There has been a lack of data on the classification of foreign body reaction to silicone injection, which can describe the pattern of body tissue responses to silicone.OBJECTIVEDetermine the foreign body reaction to silicone injection.METHODWe modified the classification proposed by Duranti and colleagues, which has categorized a FBR to hyaluronic acid injection into a new classification of an FBR to silicone injection. A cohort study of 31 women suffering from silicone-induced granulomas on their chin was conducted. Granulomatous tissue and submental skin were stained with hematoxylin–eosin and evaluated.RESULTSOur data revealed that there were at least 7 categories of FBRs to silicone injection that could be developed. Categories 1 to 4 showed inflammatory activity, and categories 5 to 8 showed tissue repair by fibrosis.CONCLUSIONUsing histopathological staining, we are able to sequence the steps of body reactions to silicone injection. Initial inflammatory reaction is then replaced by fibrosis process repairing the damaged tissues. The process depends on the host immune tolerance.
Latar belakang: Tinea pedis adalah penyakit yang ditimbulkan oleh infeksi jamur dermatofita ,yang mana penyakit ini terjadi pada daerah kulit seperti daerah punggung kaki, telapak kaki, pergelangan kaki, serta daerah interdigitalis. Pekerjaan sebagai pekerja jasa cuci mobil yang hampir setiap hari kontak langsung dengan air dapat menjadi salah satu faktor risiko terinfeksi tinea pedis. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada hubungan antara faktor kebersihan, durasi kerja, lama kerja dan pemakaian sepatu tertutup (sepatu bot) pada pekerja jasa cuci mobil dengan kejadian penyakit tinea pedis di wilayah JatibeningMetode: Penelitian dilakukan menggunakan metode potong lintang. Data diperoleh berdasarkan kuesioner dan dibantu dengan pemeriksaan fisik serta pemeriksaan KOH 10%. Perhitungan besar sampel dalam penelitian ini menggunakan metode aturan praktis, dengan jumlah sampel sebesar 30 responden. Hasil penelitian diolah menggunakan program statistik komputer SPSS memakai Chi-Square dan Mann-Whitney. Hasil dan diskusi: hasil penelitian menunjukkan bahwa semua responden berjenis kelamin laki-laki dengan mayoritas responden berusia 11 dan 22 tahun (20%) dan mayoritas pendidikan terakhir responden adalah SMA/SMK (30%). Dari hasil analisis bivariat tidak didapatkan hubungan yang signifikan antara durasi kerja (nilai p = 0,321), faktor kebersihan (nilai p = 0,637), lama kerja (nilai p = 0,794), dan pemakaian sepatu tertutup (nilai p = 0,660) terhadap kejadian infeksi tinea pedis.Simpulan: Faktor kebersihan perorangan, durasi kerja, lama kerja dan pemakaian sepatu tertutup selama bekerja tidak berhubungan dengan kejadian infeksi tinea pedis di tempat pencucian mobil di Jatibening, Bekasi. Perlu ditelti faktor resiko lainnya terhadap timbulnya tinea pedis pada pekerja jasa cuci mobil didaerah Bekasi. ABSTRACTTitle : The Correlation between the incidence of Tinea Pedis Infection and Car Wash Workers in the Jatibening RegionBackground : Tinea pedis is a disease caused by a dermatophyte fungal infection, which occurs in areas of the skin such as the back of the feet, soles, ankles, and the interdigital areas. Working as a car wash service worker who has direct contact with water almost every day can be a risk factor for infection with tinea pedis. The purpose of this study was to find out whether there is a relationship between cleanliness, duration of work, length of work and wearing closed shoes (boots) in car wash workers with the incidence of tinea pedis in the Jatibening region.Methods : The research was conducted using a cross sectional method. Data were obtained based on a questionnaire and assisted by a physical examination and 10% KOH examination. Calculation of the sample size in this study using the rule of thumb method, with a sample size of 30 respondents. The results of the research were processed using the statistical computer program SPSS using Chi-Square and Mann-Whitney.Results : the results showed that all respondents were male with the majority of respondents aged 11 and 22 years (20%) and the majority of respondents' last education was SMA/SMK (30%). From the results of bivariate analysis, there was no significant relationship between work duration (p value = 0.321), hygiene factor (p value = 0.637), length of work (p value = 0.794), and wearing of closed shoes (p value = 0.660) to the incidence of infection tinea pedis.Conclusion : Personal hygiene, duration of work, length of labour, and wearing closed shoes have no significant correlation with the incidence of tinea pedis infection at a car wash in Jatibening, Bekasi. It is necessary to find other risk factors for the emergence of tinea pedis in car wash workers in the Bekasi area.
Human adipose tissue is a great source of mesenchymal stem cells. Adipose-derived mesenchymal stem cells (AD-MSCs) are easily isolated, able to differentiate into multi-lineage cells and have various clinical application. This promising potential will be more valuable for the application of tissue engineering if they can be sequentially subcultured without loss of phenotype and multilineage differentiation ability. Thus, in this study we investigated the ability of human AD-MSCs to differentiate into osteogenic lineage by performing histological staining and studied the osteogenic potential of human AD-MSCs on early (P2, P5), middle (P10) and late passage (P15). Cells were cultured in osteogenic medium for 2 weeks and characterized at 1, 4, 7, 10 and 14 days. During sequential subcultivation, AD-MSCs were able to maintain their osteogenic potential through late passage. AD-MSCs in middle passage exhibited a better osteogenic potential than the early and late passages, while the AD-MSCs from P2 are less differentiated than middle and late passages. The result that was found in this research should be accounted for when developing stem cell-based therapies for clinical application
The use of silicone as filler material has been banned by the FDA. Nevertheless, there are still some risks of using topical silicone, particularly cosmetic products that contain silicone. Bioavailability of silicone in skin tissues and long-term complications of silicone use in cosmetic products must be evaluated for safety reasons. Silicone can penetrate to the skin by injection. Because of economic issues and the rarity of medical grade silicone, various developing countries use industrial silicone, which results in even more complications. Patients with liquid silicone injected to their nose will usually visit a doctor after experiencing complication issues such as granuloma, edema, and redness with telangiectasia. Usually the patients want to remove the silicone and treat the complication. Unfortunately, silicone is difficult to be removed completely. Some complications are difficult to treat. To handle this complication issue, the doctor has to create a specific design of nose implant, perform curettage, or remove silicone and granuloma, and then a laser treatment and steroid injection will be performed.
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