Background
Patients with primary biliary cholangitis (PBC) have decreased health‐related quality of life (HRQoL). Here, we investigate HRQoL in two cohorts of transplanted patients with PBC and compare their results to healthy subjects.
Patients and Methods
We used generic SF‐36 and disease‐specific PBC‐40 questionnaires to evaluate HRQoL in 26 patients with PBC (23 females, age 59.4 ± 5.7 years) before and after liver transplantation (LT), and in 107 patients with PBC (99 females, age 62.8 ± 6.7 years) who were previously transplanted. The control group was comprised of 60 healthy controls (55 females, age 54.6 ± 8.8 years).
Results
Health‐related quality of life improved after LT in 85% of PBC patients. The SF‐36 measure showed significant (all P < 0.05) improvements in the majority of domains after LT, and in the summary scores both physical and mental. We also documented significant improvements in pruritus and fatigue after LT (all P < 0.01). However, liver graft recipients had significantly worse physical functioning, physical role, and emotional role domains, and physical component score (all P < 0.001), as compared to healthy subjects. No differences in HRQoL were detected between patients evaluated after short and prolonged post‐LT periods (P > 0.05).
Conclusion
Liver transplantation substantially improves most aspects of life quality in PBC patients. Nevertheless, their HRQoL remains worse in comparison to healthy individuals, mainly in physical aspects.
INTRODUCTION The main goal of transplant care is to achieve the best long-term patient survival (PS) and graft survival (GS). Since the introduction of kidney transplantation to clinical practice in 1954, PS and GS have improved thanks to advances in surgical techniques, perioperative care, and immunosuppression (IS) treatment. 1-4 However, for the last 2 decades, there have been no further improvements in this area. 4,5 This is partly
BackgroundThis study is to evaluate the early results treatment of patients with total occlusion of the left main coronary artery. Total occlusion of the left main coronary artery is a very rare finding in patients with acute coronary syndrome. In these cases, patients present various clinical symptoms, however the symptoms and the survival of these patients depend on the development of collaterals and adequate medical intervention.
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